arrhythmia therapy and drugs Flashcards

1
Q

what conditoin are classed as arthymias

A

sinus arrhytmias, bardycardia, tachycardia, superventiuar arrhytmia, atrail fibrillon, svt junutoial, ventralar arrhythmia, vventicalry tachyat, venticlay fibrialoin

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2
Q

class 1 drug type

A

1a - moderase soium channel bloackade
1b - mild soium channel blockdade
1c - strong soidum chnnle blocka
all reduce amplude of ap and condition velocity

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3
Q

example of class 1a

A

quinidine, procainamide, dispyramide

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4
Q

examples of 1b

A

lidocaine, mexiline, tocainde

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5
Q

type of 1c

A

flecaiinde, propafenone

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6
Q

what is type 2

A

b blocker
bdaer recpoat antagoins -0 slow sa disace and av onduoi, shortens phase 4 and stage2

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7
Q

what is class 2 examples

A

atenonl, bisoprolol

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8
Q

what is class 3 examples

A

amiodarone,, bretylium, sotalol

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9
Q

what is class 4 exampels

A

diltiazem, verapamil

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10
Q

what is class 5 examples

A

dioxina, adenosiin

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11
Q

what do class 3 do

A

pronlon reflaion, slow k out of cell , increase aciton potiel durion, prolign replion stage 3

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12
Q

when can class 3 potaium chanel blockers bue used, l

A

life threating ventriular tachycaria or fibrilaion, atrial fibrion or fluttoier restiant to other drugs

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13
Q

what are amiodarmine used for

A

superveniucar tachyarida

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14
Q

what drugs does aminodarone react with

A

digoxin

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15
Q

what are some of the side effects of amiodarone

A

thryois, pulomary firois, slate, corenal deposions, lft abdnomaleis

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16
Q

what drugs are class 4

A

ccb , depres phae 4 depolisoin in sa and av nodes, slow heart rate down, decrease automatoricy shortens phase 2 plu by shorin ca2+

17
Q

what are class 5 drugs o

A

other antiarthy

18
Q

what is eh efect of dioxin

A

increased val tone, increase ca2+

19
Q

what is indicoitn for use of digoxin

A

atrial fibrialion, atrali flutter, svt, heart failure

20
Q

what are signs of diogein toxity

A

nausea and vomitin, xanthopsia, bradycarida, tachycarida, arrhymias, vt and vf

21
Q

wht is the effet of adenosiin

A

bind to the adensio recptr, blocks condiont through av nodes, opens k channesl,, incrase camp levsi which inhigb ca2+
hperpolase the cell to prevent depolases
h

22
Q

what i the reverase agento digoxin

23
Q

how is adensoide admisterd

A

fast pused though iv

24
Q

what are vitamen k angatons

25
what are directi thromhin inhitor exampoles
dabigatran
26
whta are direct xa inhitosr examples
apixaban, rivaroxabmn, edoxaban
27
what is thechane in prothbin time when suign warthin
up to 2.5- 4 times increase
28
what is the side effedct so warfarin
bleeing, interaciton with other drus, pregancy - teratogenic, avoid in 1st and 3d trimesters
29
what is the effect of aspirin and sulfonamides on warfin
decreased bining to albumin,increign it activty - albuit decres it bioavialbtiy
30
what is the effect of cimetidein and erythromycin on warfarin
inhibis degredation, increasein it acttivty
31
what is the effects of antibiotc oin warfarin
decreased symthes of clotting facots, increase ing its actiyt
32
hw does heapring promt bleeing
supers clotitng factors
33
what drugs supres warfarin actigy
barbituase and pheyoti as p450 vit k - promoe clting factor symtes cholesytine - reduce absobrion
34
what are direct anticoat
apixabn, rivaroxabn, edoxabn
35
drusg which are cytochrme p450 inducters
Cytochrome p450 infludcs – alcohol barbiutes, carbanzmein, pheytopin, rifampicin, sulphonylureas
36
drugs which are cytochrome p450 inhibitors
omeprazonle Disulfiram Erythommycin Sodium Valproate Isoniazid Ciprofloxacin and cimetrine ethanol sulphonamides