Signal Transduction - Intracellular Ligands

Question 1

What is an important intracellular receptor ligand?

Answer 1

Steroid hormones e.g. glucocorticoids

Question 2

Why are steroid hormones important in dentistry?

Answer 2

Negative effect in calcium balance

Bone

Question 3

How are glucocorticoids important in the immune system?

Answer 3

Important and potent anti-inflammatory

Question 4

What common characteristic do intracellular ligand have?

Answer 4

Lipophillic

Hydrophobic

Question 5

Why are glucocorticoids only prescribed for a short period of time?

Answer 5

Very potent and can have side effects

suppress immune system

Question 6

What genes do the steroid hormones switch off?

Answer 6

cyclo-oxygenase

iNOS

IL-1, IL-6

TNFalpha

Question 7

What are 3 are examples of intracellular receptor ligands?

Answer 7

thyroid hormones

retinoic acid

vitamin D

Question 8

What is Vitamin D associated with?

Answer 8

Ca2+ homeostasis

Question 9

Do steroid hormones have a quick or slow effect?

Answer 9

sow onset physiological response

Question 10

How long do the effects of steroid hormones persist for?

Answer 10

long periods of time