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BDS2.5 Applied Biomedical Sciences > Neurones: Synaptic Transmission > Flashcards

Neurones: Synaptic Transmission Flashcards

1
Q

What do chemical synapses use?

A

Neurotransmitters

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2
Q

What does lidocaine do to AP?

A

Disrupt AP propagation

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3
Q

What do barbiturates do?

A

Disrupt synaptic transmission

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4
Q

What drug is used in Alzheimer’s?

A

Anticholonesterases

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5
Q

Most widely studies synaptic junction?

A

NMJ

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6
Q

When the ach binds the nicotine cholinergic receptor, what occurs?

A

Potassium out and sodium in

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7
Q

Opening of what channel generates the AP?

A

Voltage gated sodium channels

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8
Q

What is dopamine?

A

Single amino acid

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9
Q

Name types of excitory amino acids

A

Dopamine
Glutamate
Aspartame

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10
Q

Name inhibitory amino acids in brain?

A

GABA

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11
Q

Name inhibitory amino acid in the spinal cord?

A

Glycine

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12
Q

Name types of peptides

A

Substance P
Opioid peptides

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13
Q

What is the role of peptide substance P?

A

Pain

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14
Q

What is the role of opioid peptides?

A

Block pain

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15
Q

Name types of purines

A

AMP and ATP

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16
Q

Name types of gases

A

NO and CO (retrograde signalling)

17
Q

Name types of lipids

A

Cannabinoids
Eicosanoids

Both retrograde and involved in intracellular signalling

They tone things down

18
Q

Where is glutamate found?

A

CNS

19
Q

What are muscarinic receptors linked to?

A

GPCR

20
Q

Where are alpha adrenergjc receptors found?

A

Nerve terminals

21
Q

Where are beta adrenergic receptors found?

A

Muscles -heart and skeletal

22
Q

What receptor is associated with nicotinic receptors?

A

Hippocampus … Alzheimer’s

23
Q

What do nicotinic receptors facilitate?

A

Monovalent cation channels

24
Q

What ach receptor is found in the CNS?

A

Glutamate

25
Q

What is the role of glial cells neuotransmission?

A

Indirectly inhibit neurotransmitter in the synapse

Pump back into nerve terminal for reuse

26
Q

How can neurotrasmission be inhibited?

A
  1. Transported into glial cells
  2. Returned to axon terminal for reuse
  3. Enzymes inhibit neurotransmitter
  4. Recycling it
27
Q

What neurotrasmitters low for EPSP?

A

Glu
Ach

28
Q

What are the IPSPs?

A

GABA
Gly

29
Q

What receptors are the slow synaptic potential?

A

GPCR

30
Q

What receptors allow fast synaptic potentials? And what does this result in?

A

Ligand gated ion channels

Ion channels close (less Na in less K out)

31
Q

What is presynaptic inhibition?

A

Inhibitory neurone at the axon terminal - it’s a selectivity

32
Q

What is post-synaptic inhibition?

A

All targets will be inhibited equally

BDS2.5 Applied Biomedical Sciences (48 decks)

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