endocrinology 4 - adrenal cortex Flashcards
Name the 3 zones of the cortex?
What does the zona reticularis produce?
sex hormones
(low affinity androgens)
What does zona fascicularis produce?
glucocorticoids (cortisol)
What does the zona glomerulosa produce?
aldosterone
name 3 types of cholesterol (steroid hormones)
aldosterone
cortisol
sex hormones
What type of secretion regulates glucocorticoid release?
diurnal rhythm (it has a circadian rhythm but can be induced)
–> inducible in response to stress
i.e a rhythmic inducible release
Name the primary glucocorticoid
cortisol
What hormone is released from the hypothalamus to stimulate ACTH?
CRH
ACTH promote cholesterol to make cortisol
What tissue doe cortisol have an effect on?
IMMUNE system
liver
muscle
adipose tissue
What does ACTH bind in the adrenal cortex?
membrane-bound receptors on cells of zona fasciculata
What is the long-term mediator of stress response?
cortisol
Does cortisol help with hypoglycaemia?
yes
opposes insulin
How does cortisol prevent hypoglycaemia?
stimulates gluconeogenesis
breaks down fat and uses A as energy source
breaks down protein into AA for use as energy source
What is gluconeogenesis?
glucose form non-carbohydrate source
(not glycogen)
can use glycogen if it really needs to
How does cortisol have an effect on immune function?
supress inflammatory immune response
Does cortisol help with proper development?
yes
What effect does cortisol have on brain function?
mood
learning and memory