Innate Immunity Flashcards
What are the professional phagocytes?
Monocytes
Macrophages
Granulocytes
Dendritic cells
How long does the innate immune response take to activate?
0-4 hours
When the macrophage engulfs the pathogen, what is the pathogen encased in?
Phagosome
What does the phagosome fuse with?
Lysosome
What is inside the lysosome?
Chemicals and enzymes
What is a monocyte?
Immature macrophages
When monocytes become macrophages, where do they reside?
Tissue
What do you call the fraction of the pathogen which macrophages display in their cell surface?
Antigen
What do the macrophages displaying a pathogenic antigen on surface display it to?
mhc2 complex
What is the difference between MHC1 and MHC2?
MHC1 = cells with a nucleus and express as antigen on the MHC1
MHC2 = antibody response
What is the ,last abundant WBC?
Neutrophils
Compare neutrophil and macrophage
Neutrophils are not APC, just eat pathogen
What do NKC do?
Phagocytose cells
Do the NKC use the roll-stop-exit method?
Yes
What do the NKC secrete?
Perforin
How do the NKC kill cells?
MAC complex = suicide
FasL interact with Fas on the surface of target cell = suicide
What does IL-12 and TNF from the macrophage cause the NKC to do?
Recruit and activate NKC
What does IL-2 secreted by the NKC cause the NKC cell to do?
Proliferate
In turn, what does the NKC secrete to recruit and activate more macrophages to amplify response?
IFN-y
What MHC does the NKC detect?
MHC1 as it is innate immune response
What at the 2 types of inflammatory inflammation?
Acute or chronic inflammation