Signal Transduction - GPCR Flashcards
What receptor is shown?
GPCR
Can the effector of a GPCR be an ion channel?
Yes
Where does the receptor exist in a GPCR?
Plasma membrane
What 2 receptors can the G protein activate?
Enzyme or ion channel
What are seconds messengers?
Transfer a signal from the membrane to the rest of the cell
After (receptor activation)
soluble products
intracellular site of action
amplify the response
When the ligand activates the GPCR, is the signal continuous?
Yes
What is the chain of events in the GPCR?
What do second messengers do?
What are 4 examples of effectors in a GPCR?
What are examples of GPCR? (receptor)
What is the second messenger of adenylate cyclase effector?
cAMP
What is reaction of adenylate cyclase to camp?
ATP to CAMP + PPi
Can adenylate cyclase link inhibitory and stimulatory receptors?
Yes
regulated by Gs and Gi
What are the stimulating receptors adenylate cyclase?
Beta adrenergic
ACTH
What are the inhibitory receptors of adenylate cyclase?
Alpha 2 receptors
Muscarunic
Opiate
GABA b