sensory systems and pain physiology Flashcards
what to pancilan corpuse respond to
deep pressure
what do ruffini corpuscles respond to
warmth
what do meissener copurs respond to
light touch
what do merkels corpus respond to
touch
funciton of free nerve endings
pain
what signifies the intesity of a stimuls
frequency of action potential
how to determine where a stimulous is from
receptive feild
what is the trigger zone
area wher a transution sings turns into action poteials
what is a recepive feild
area of stimuls that is applied, it is area where it connects to other protcepotrs
what are hte types of cutanoes sensoation fibers
ab, Aδ an C
what is ab
large myelatied
spped of ab
30 -70m/s
what does ab meausre
touch, pressure and vibration
what is Aδ
small myelatied
speed of Aδ
5 - 30m/s
what does Aδ meause
fast paina nd pressure
what is c fibers
small unmeya.ted
spped of c fibers
0.5 - 2m/ s
funciton of c fibers
warth and slow pain
where to they enter the spinal cord
dorsla root ganglia
wher ot crial nerves enter spial cord
cral nerve ganglia
what are the mechano recpigve fibers
aa and ab
fibes for protecption
aa and ab
aa fiber
muscle spiner lfierb with fastes spped
where do mechang repite fiebrs synape
cunetate and gracile nulcie in the medulla
which tract do mechanorepcoi go up
isilatarl dorsal columbs
where do the mechanorective fibers cross
over the midline in the brain stem and to the restic formation and thalamus
what type for fibesr are thermorecpive and nociepetie
Aδ and c
where do thermo and noticerep fibers sysnape
dorsal horn
what is the course of the thermocrepa nd notercpic fiebrs
cors midline of spinal cord after synaping in it
and go up later spinothalic tract to reticuar foramnat, thaalmau and cortex
what is brown sequard synomde
where contralateal side loses pain and temparute
and ispilati side lose, viraion, motor funciton, deep touhg and proipoception
where doe sthe termiation occur
somatosensory cortex of the post cental gyrus
what is rapidly adapting cells
they change quickly to ignaor stimul, stopping seeing acitno potiona
what are slowi adamping cells
they don’t sop seing aciton protional against a stimulus
benifits of converges
reduces no. of nurions,
downsides of convergence
reduces acuity
what are speific asing pahtwyas
where there are sperate htings for things like touch and temparues
non specfici ascening pathway
same pathway for both temperature and touch
what is latarl inhibitoin
where one sensory inputs actiion cuase inhibtion of a neighbour
what happesn to frequeyc of action potens in neihgt bof a latarl inhbing neruon
it drops below frequency , making it look like it si not there at all
what are the types of pain
sharp, stabing difues , fast or slow, acute, chronci, viscer, refered , phantom limbpain
how are signa transion of pain acitved in nociecptors
low ph or heat
local cemicla meidatiors
examples of local cehmcial meidator in nociceptors
bradykinin, histamine, prostaglandins
what are exampoles of low ph and heat sencors
asic and trpv
how is asic funcitons
it opens an ion channel and releases soiudm into a cell to relaea an action potential
what happens with activating periaqudaclt gray matter
it causes the inhition of pain though sending signal to the nucleus raplh
how does the nuclus rahe mangus inhibt pain
reaslses serotoion which project down to the doral horne nuclear to block pain at that level
what type of recprot is on the pag
opiod
what type of fibers are need to activate inhibitor fibers of pag
aa/ ab
gate contorl thearpy
block pain signsal of ad/ c fibers
what do the nuclouer raphe relse
endoprones/ opoids pepistes
whre do the opoid peptities travle down
doral spinothla colub
how to nsaids work
inhibit cyclooxygenase stoping arachoni acids turnign to proslagins
how to prostaglins work
they snesity nocipetor to bradykinins
what are bradykinins
a peptise that cuases inflmatoatino
vasodialte
edmea
muscle contraction
what typ eof pain if nsaids effective agianst
ones that cause infolaton
how does lcoal anathic work
block na action potpan and thus all axonal tranaiotn
how to morpones work
reudce senicve of nociapes, block transmait in doral horn through epidural transioant
activate desncing hinhigor pathawy
what is cox1
for prosuicng gastic muous
help kindesy
produce platel
what is cox 2
infmalton, pain fever and inhibit palteles
