Neuropharmacy Flashcards
what are the stages of synaptic transmissoin
1 - synthesis and packing of neuro transmitter
2 - na actio protoensl reahces terminal
3 - activates voltage gated ca 2+ channels
4- triggers ca2+ dependent exocytosis of prepackaged vesicles of transmitters
5 - transmitters diffuse across the clef stand binds to the ionotrpic and or metablictopic recpotr to cause a post synaptic effect
6 - presynaptic repcots inhibit further release
7 - transmitter is inactive by uptake of glia or neurosn
8 - transmitter is metabolised within the cells
how do locan anethisc work
they block voltage gated na channesl, prveing activiation of the action portie working on cell
how does competive and non competice antagoists work
they work on the site of the ionotproc or metabolic recpot, stopping the transmitter form functions
how does spider vemon work
block voltage gagted ca 2+ channles
where do ca molueues move
into the cell
how does botlumim work
it blocks the rlase mahcine of neurotransmitters
how do ssris work
block the uptake of hte transmiter, meing more goes bakc into cells
how does benzodiapepieze work
they make the effect of the tranmsiter stronger on the receptor
where does dopamine distrobute to
brianstem
basal ganglia
limbic sytem and frontal cortex
what does dopamine control
vommiting
emotions
voluntary movemnet
what does parkinsons cause
degerneation of da cells in the sn
da defeciency in the basal ganglia
what chemicals can turn into the dopamine and cross bbb
tyroseins and dopa
what is the issue with having lots of dopa in periphery
nauesa
vommiting
psycois
why can tyrosine not be converted to dopaine in the rbain
as it becomes lost though degeneration
what is dopaine broken down to
homovanillic acid
signs of parkingons
change in posture
stiffness
tremor
slow movements
what are da precurus exmales
levodopa
what drugs are da agonists ergots
bromocriptine
pergolide
cabergoline
non ergot drugs
ropineiprole
pramipexole
rotigotine
is the area postrema (vommiting cnetre ) in the perhiary or in brain
in the perhiphary
example of da antagoinstis that do not cross bbb
domeridone
risk of domperidone
qt prolongation
what is dyskinesias
abnroal or involuntary movements , due to too mcu movement, due to excessive dopaimine
what drugs cause dyskineiase
dopamingeric drugs
