pain Flashcards
what are the 3 types of pain
nociceptive
neuropathics
nociplastic
what si nociceptive
pain region localised at site of injuy
can be chonric
fixed by analgesic
what is neuropathic pain
pain that is not necesary at same side of injyr
e..g nerve root pain, or sutulai pain
does not respond well to anagleis
what is nociplatic pain
pain where there is no inflamtion or change
due to change in central prlacity , where there is no prtovecig function
what is an allodynia
some one who as a substancy decreaed pain threshold, ie is in pain when there is no stimulus
what is hyperalgesia
exaturated respons to noraml stimuli
what is main differnce between allodynia and hyperalgesi
hyper alges stimuls does cause pain normlly and allodynia does not
difference bteen innocuous and noxious pain
noxiou nomral injury response and pain grade, innocous, pain shifted to the left thus an injury
what is centrla sensiation
response of second order neruons to noxious an non noxious stimuli
what are the 3 components of central sensitiazation
windup
classical
long term potentiation
wind up
actiated synapes
what molveu mediates winu up
subsatnce p and cgrp
differnce betwen nociecption and pain
nociepcion is singla of pain, and pain is response to nociep, ie. hhow it is received
type sof neuroceptois
alpha delta mechnosentive
alphadeleta mechanothermal
polynodal nurorecptors
what is the process of central sensation classical pathway
involves the opening of new synapes
it has assocated plasccitiy
outlasts the intial stimulil
what levels of stimuli is central sesnation classical operate at
low levels
when does long term potentiation occur
for very painful and intense stimuli
when do trpv1 ion chanle reson
damage from heat as well de to capsuacin, from chiilii peppers
what are teh chemcial that can lower the threshod notcieps operate at
histamine, prostaglandin, serotonin, and substance p and bradykinks
what is long term potentai assocated with
chronci pain
where does adelta synapes in teh doral horn of teh spinal cord
laminae 1 and 5
wehre does c synapse in the dorsal horn of the spinal cord
lamina 2
where is a delta mainly foudn
body surface, msuesl and joinst
wher is c mainly found
tissues
what are the types of neruons present in the spidnal cord
low threshold
wide dynamic range
nociceptive
what do nocieptic neruon do
respon to high threshold pain
where are nociecptive neruon found
lamineae 2 and 3
what are wide dynamci range dunutes
they resond to a range of sensry stimuli
where are wide dynamic range neruons found
laminae 5 and 6
role of low thresh nuclie
respond to innocuosu stimul
which laminae does spinothalic tract contae
1 and 5 (a delta fibers termiate pont
what is the roel of lateral tract in pain
shows where the sensory level of pain is
what is the role of the medial tract for pain
aurtomic adn affective part of pain
what is the periaqueducat grey mater
it contain noradrenalie neruons , which surroudn the cerbal aqueduct of the midbrain
role of periaqueducal aqudict
it can activae analgesia, espcially due to morphine , electrical stimulation
what does the periqudace duct grey matter project do
lamina 2 and nucle raphe magnus
what is the nucleous raphe magnus
it reasles serotin which acts as a interior internuona to prevent pain
does serotoin increase or decrease pain
both depending on which pathway that it is activated at
where does nucleous raphe maguns project to
lamina 2 and 5
what does vicle pain respond to
distention , inflamation and ischemia
capsacin work on what recptor
trpv1
role of nerve growth factor
sensitises nociceptor
role of cannaboids in pain
act on cb1 recpronsa and invoed in pain prevention
what does cholcytokinin act on
drg and dorsal horn and tract in vicearl pain
role of enkephalin and beta endorpahin
assocaed with pain, and prevnet hte opid recpro working
nitic oxide and pain
it is assocad with pain in the perhal and central reioa dn also invoeld in part of brain neuoplascity
