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CNS > pain > Flashcards

pain Flashcards

1
Q

what are the 3 types of pain

A

nociceptive
neuropathics
nociplastic

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2
Q

what si nociceptive

A

pain region localised at site of injuy
can be chonric
fixed by analgesic

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3
Q

what is neuropathic pain

A

pain that is not necesary at same side of injyr
e..g nerve root pain, or sutulai pain
does not respond well to anagleis

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4
Q

what is nociplatic pain

A

pain where there is no inflamtion or change
due to change in central prlacity , where there is no prtovecig function

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5
Q

what is an allodynia

A

some one who as a substancy decreaed pain threshold, ie is in pain when there is no stimulus

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6
Q

what is hyperalgesia

A

exaturated respons to noraml stimuli

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7
Q

what is main differnce between allodynia and hyperalgesi

A

hyper alges stimuls does cause pain normlly and allodynia does not

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8
Q

difference bteen innocuous and noxious pain

A

noxiou nomral injury response and pain grade, innocous, pain shifted to the left thus an injury

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9
Q

what is centrla sensiation

A

response of second order neruons to noxious an non noxious stimuli

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10
Q

what are the 3 components of central sensitiazation

A

windup
classical
long term potentiation

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11
Q

wind up

A

actiated synapes

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12
Q

what molveu mediates winu up

A

subsatnce p and cgrp

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13
Q

differnce betwen nociecption and pain

A

nociepcion is singla of pain, and pain is response to nociep, ie. hhow it is received

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14
Q

type sof neuroceptois

A

alpha delta mechnosentive
alphadeleta mechanothermal
polynodal nurorecptors

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15
Q

what is the process of central sensation classical pathway

A

involves the opening of new synapes
it has assocated plasccitiy
outlasts the intial stimulil

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16
Q

what levels of stimuli is central sesnation classical operate at

A

low levels

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17
Q

when does long term potentiation occur

A

for very painful and intense stimuli

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18
Q

when do trpv1 ion chanle reson

A

damage from heat as well de to capsuacin, from chiilii peppers

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19
Q

what are teh chemcial that can lower the threshod notcieps operate at

A

histamine, prostaglandin, serotonin, and substance p and bradykinks

20
Q

what is long term potentai assocated with

A

chronci pain

21
Q

where does adelta synapes in teh doral horn of teh spinal cord

A

laminae 1 and 5

22
Q

wehre does c synapse in the dorsal horn of the spinal cord

A

lamina 2

23
Q

where is a delta mainly foudn

A

body surface, msuesl and joinst

24
Q

wher is c mainly found

A

tissues

25
Q

what are the types of neruons present in the spidnal cord

A

low threshold
wide dynamic range
nociceptive

26
Q

what do nocieptic neruon do

A

respon to high threshold pain

27
Q

where are nociecptive neruon found

A

lamineae 2 and 3

28
Q

what are wide dynamci range dunutes

A

they resond to a range of sensry stimuli

29
Q

where are wide dynamic range neruons found

A

laminae 5 and 6

30
Q

role of low thresh nuclie

A

respond to innocuosu stimul

31
Q

which laminae does spinothalic tract contae

A

1 and 5 (a delta fibers termiate pont

32
Q

what is the roel of lateral tract in pain

A

shows where the sensory level of pain is

33
Q

what is the role of the medial tract for pain

A

aurtomic adn affective part of pain

34
Q

what is the periaqueducat grey mater

A

it contain noradrenalie neruons , which surroudn the cerbal aqueduct of the midbrain

35
Q

role of periaqueducal aqudict

A

it can activae analgesia, espcially due to morphine , electrical stimulation

36
Q

what does the periqudace duct grey matter project do

A

lamina 2 and nucle raphe magnus

37
Q

what is the nucleous raphe magnus

A

it reasles serotin which acts as a interior internuona to prevent pain

38
Q

does serotoin increase or decrease pain

A

both depending on which pathway that it is activated at

39
Q

where does nucleous raphe maguns project to

A

lamina 2 and 5

40
Q

what does vicle pain respond to

A

distention , inflamation and ischemia

41
Q

capsacin work on what recptor

A

trpv1

42
Q

role of nerve growth factor

A

sensitises nociceptor

43
Q

role of cannaboids in pain

A

act on cb1 recpronsa and invoed in pain prevention

44
Q

what does cholcytokinin act on

A

drg and dorsal horn and tract in vicearl pain

45
Q

role of enkephalin and beta endorpahin

A

assocaed with pain, and prevnet hte opid recpro working

46
Q

nitic oxide and pain

A

it is assocad with pain in the perhal and central reioa dn also invoeld in part of brain neuoplascity

47
Q
A

CNS (36 decks)

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