Schizophrenia And It’s Causes Flashcards
Schizophrenia MZ:DZ?
45:15%
Major histocompatibility complex on which chromosome?
6
Biological stress factor of schizophrenia?
Immune activation, premature birth, low birth weight, perinatal hypoxia, intrauterine infection, ante-partum bleeding
Hypofrontality causes?
Negative symptoms
Increased dopamine in nucleus accumbens causes?
Positive symptoms
Drugs causing schizophrenia?
Amphetamine ketamine, LSP, cannabis,cocaine, LDOPA
Organic psychosis?
Epilepsy, cerebral trauma, encephalitis, demyelination, neurodevelopmental disorders, endocrine disorders, drugs, toxins, dementia
Resistant cases of psychosis should be treated with?
Clozapine
Olanzapine causes?
Weight gain side effect due to binding at histamine receptors
Blocking alpha 1 receptor?
Postural hypotension
Blocking dopamine receptors?
Neuroleptic malignant syndrome
Hypotension arrhythmia
Parkinsonism symptoms
Raised prolactin
Atypical antipsychotics side effects
5HT2 receptors
Metabolic, raised prolactin, sedation, neutropenia with clozapine
Clozapine can cause?
Neutropaenia, also dribbling
Electroconvulsive treatment to treat?
Psychosis associated with depression, or with catatonia
Side effect of ECT?
Short term memory loss