Cerebellum And Motor Learning Flashcards
Cerebellum division?
Vestibulocerebellum
Spinocerebellum
Cerebrocerebellum
Vestibulocerebellum found in?
Flocculonodular lobe?
Cerebrocerebellum projects onto?
Hemispheres
Spinocerebellum projects onto?
Vermis
Hemispheres project onto?
Dentate nucleus
Vermis and paravermis project onto?
Fastigial and interposed nucleus
Flocculonodular node projects onto?
Vestibular nuclei
From Dentate nucleus projection to areas?
4 and 6
Dysmetria?
Movement not stopped in time, overshoot
Dsynergia?
Decomposition of complex movements
Dysdiadochokinesia?
Reduced ability to perform rapidly alternating movements
Intentional tremor/
Tremor arising when trying to perform a goal directed movement
Dysarthria?
Incoordination in respiratory muscles, and larynx, uneven speech strength and velocity
Medial longitudinal fasciculus?
Area of crossed over tracts
MS a common cause
Nystagmus
Involuntary rhythmical repeated oscillations of one or both eyes
Gait ataxia?
Lesion in spinocerebellum pathway and disturbance of limb tone
Mossy fibres from?
Pons, brainstem and spinal cord
Climbing fibres from?
Inferior olive medulla
Cerebellum cortex functioning?
Mossy fibres synapse with granule cells which form parallel cells.
Many parallel fibres to a singly purkinje cell. One Climbing fibre would synapse with one purkinje cell, then to deep motor nuclei
LTD motor learning?
Glutamate from parallel fibre bings to mGluR causing chain of reaction so IP3 forms.
Which binds to receptor on endoplasmic reticulum allowing calcium to release, which comes from climbing fibre depolarising voltage gated channel.
So internalisation of AMPA receptors so weakening of parallel and purkinje cells
Cerebellum dysfunction causes?
Genetic, spinocerebellum degeneration, Frederichs ataxia
Alcohol, metabolic (B12,thyroid) Drugs
degenerative (Parkinson’s)
Immune (paraneoplastic)
