Basal Ganglia

Question 1

Direct pathway?

Answer 1

Cortex to striatum excitatory
Striatum to global pallidus inner-inhibitory, unable to inhibits thalamus, which causes excitation of cortex

Promotes movement

Question 2

Indirect pathway?

Answer 2

Cortex to striatum excitatory, striatum to global pallidus external inhibitory, which is unable to inhibit subthalamic nucleus causing global pallidus internal excitation, which is able to inhibit thalamus preventing any excitation to cortex.

Question 3

Hyper direct pathway?

Answer 3

Cortex causes excitation of subthalamic nuclei, causing globes pallidus internal to inhibit thalamus, so unable to excite cortex.

Question 4

Striatum neurons, medium spiny neurons?

Answer 4

Direct - D1, increase activity excitatory DA increase

Indirect D2- inhibitory DA dampens

Question 5

Neostriatum?

Answer 5

Caudate and putamen

Question 6

In Direct D1 neurons?

Answer 6

Ach dampens down

Question 7

Ach opposes effects of?

Answer 7

DA