Regulation of Ion Channels

Question 1

Ligand-gated channels

Answer 1

Binding of a specific molecule to a binding site on the channel causes a conformational change that opens the channel; Selectivity is conferred by charged amino acids (cations vs. anions) and size

Question 2

Voltage-gated channels

Answer 2

A change in membrane potential moves charged molecules within the channel. Charged amino acids causing a conformational change in the channel opening the channel

Question 3

Mechanosensitive channels

Answer 3

Stretch of the membrane may affect the channel conformation either opening or closing the channel

Question 4

Visceral Sensory-Pain caused by 4 sources:

Answer 4

1.Stretch/distension
2.Inflammation
3.Ischemia
4.Smooth muscle spasm

Question 5

Physiological Processes of the visceral sensory system

Answer 5

Temperature changes, chemical changes, hunger, nausea, physiological reflexes