Fibrous Proteins, Proteoglycans and Glycoproteins Flashcards
A scientist investigates the enzymatic activity of lysyl oxidase. Which of the following best describes this enzyme?
Needed for both, collagen and elastin synthesis
A research group investigates the prevention of scurvy related to dietary changes. They study the change in amount of hydroxylation of proline residues in collagen with changes in the diet in experimental animals. Which of the following best describes the function of these modified amino acid residues in this protein?
Stabilize the collagen triple helix.
A research laboratory isolates a cell surface integral protein in which a branched carbohydrate oligosaccharide chain is linked to a serine residue of the protein moiety. Which of the following macromolecules is most likely isolated by the laboratory?
O-linked glycoprotein
A graduate student has purified a glycosaminoglycan from the vitreous humor of the eye and the synovial fluid of patients during eye surgery and from patients during knee replacement surgery. Which of the following best describes the isolated macromolecule?
Synthesized in the extracellular space.
A 26 year old woman is brought to the emergency department following a car crash. Physical examination shows pain and swelling of her right ankle. An x-ray of the right ankle shows multiple fractures. Internal fixation of the broken bones is performed. She is regular intraabdominal injections of heparin as an anticoagulant following the surgery. Which of the following best describes this anticoagulant?
GAG contained in mast cells
A research group investigates specific serum proteins released from the liver into the blood and focuses on N-glycosylation. Which of the following best describes this type of glycosylation?
A mannose-rich oligosaccharide is synthesized bound to dolichol pyrophosphate
A 6 month boy is brought to the physician by his parents for a follow-up examination. He was diagnosed with Hurler syndrome which is due to excessive accumulation of heparan sulfate and dermatan sulfate. Laboratory studies show a defect in the degradation of these macromolecules due to an inherited enzyme deficiency. In which of the following organelles is this enzyme most likely located in normal individauls?
Lysosomes
