Lymphatic System

Question 1

Cells that synthesize IFN-gamma, IL2, TNF
-Activate macrophages to destroy intracellular pathogens

Answer 1

TH1 cells (T lymphocytes)

Question 2

Cells that synthesize IL4, IL5, IL10, IL13
-Activate eosinophils, mast cells, and B lymphocytes (for IgE production) to destroy extracellular parasites

Answer 2

TH2 cells

Question 3

Synthesize IL-17 and IL-22
-Destroy extracellular bacteria and fungi by recruiting neutrophils to the site of inflammation

Answer 3

TH17

Question 4

Cytotoxic T lymphocytes express:

Answer 4

CD8 (cell differentiation factor), participate in cell-mediated immune response
-Target and destroy transformed or virus infected cells (also parasites and transplanted cells)

Question 5

What % of circulating lymphocytes are natural killer lymphocytes?

Answer 5

5-10%

Question 6

Natural killer lymphocytes release the following enzymes:

Answer 6

Granzymes and perforins

Question 7

Which type of lymphocytes participate in humoral immunity?

Answer 7

B lymphocytes

Question 8

Which type of MHC receptor do B lymphocytes express on their surface?

Answer 8

MHC II

Question 9

Primary Lymphoid Organs

Answer 9

1) Bone Marrow
2) Thymus

Question 10

Secondary Lymphoid Organs

Answer 10

1) Lymph Nodes
2) Spleen
3) Tonsils
4) GALT: Gut associated lymphoid tissue

Question 11

Where are Hassall’s Corpuscles found?

Answer 11

Only in the thymic medulla and consist of rings of degenerating epithelial reticular cells.

Question 12

Portion of the lymph node that contains dense connective tissue

Answer 12

Capsule

Question 13

Which part of the lymph node contains an abundance of B lymphocytes?

Answer 13

The outer cortex

Question 14

Which part of the lymph node contains an abundance of T lymphocytes and no nodules?

Answer 14

The inner cortex/paracortex (area between outer cortex and medulla)

Question 15

Area of the lymph node where blood vessels and nerves enter and leave

Answer 15

The hilum

Question 16

Convey lymph toward the node and enter it at various points on the convex surface

Answer 16

Afferent lymphatic vessels

Question 17

Convey lymph away from the node and leave at the hilum

Answer 17

Efferent lymphatic vessels

Question 18

What type of collagen do reticular cells secrete?

Answer 18

Collage type III

Question 19

HEVs are located in which part of the lymph node? (medulla, deep cortex or superficial cortex)?

Answer 19

The deep cortex, paracortex

Question 20

Increase in number and size of cortical lymphoid follicles

Answer 20

Follicular Hyperplasia
-Humoral response

Question 21

Expansion of paracortical zone and response to viral infection

Answer 21

Paracortical hyperplasia

Question 22

Medullary sinuses are extremely prominent-draining necrotic tumor

Answer 22

Sinus hyperplasia