Muscle Physiology

Question 1

Condition in which auto-antibodies destroy and reduce the number of nicotinic receptors

Answer 1

Myasthenia Gravis

Question 2

Condition in which auto-antibodies destroy and reduce the number of voltage gated calcium ion channels

Answer 2

Lambert-Eaton Myasthenic Syndrome

Question 3

This toxin blocks the release of acetylcholine from the presynaptic terminal and often used in Botox

Answer 3

Botulinum Toxin

Question 4

Plant derived alkaloid that competes with acetylcholine for nicotinic receptors

Answer 4

Curareis

Question 5

Venom of the black widow spider that opens presynaptic calcium channels resulting in excess acetylcholine release

Answer 5

Latrotoxin

Question 6

Isometric muscle

Answer 6

Muscle length at rest

Question 7

Isotonic muscle

Answer 7

Muscle length is shorter at rest due to contraction

Question 8

Malignant Hypothermia

Answer 8

Excitation contraction coupling where mutations or dysregulation of calcium release channels in the muscle (ryanodine receptors)

Question 9

Treatment for malignant hypothermia

Answer 9

Dantrolene (binds to RyR receptors)