Reduce Clotting Flashcards
What are platelet aggregation inhibitors used for
Primary Hemostasis
What are anticoagulants used for
Secondary Hemostais
What are the Platelet Aggregation Inhibitors
Aspirin Clopidogrel Ticlopidine Dipyridamole Cilostazol Abciximab Eptifibatide Eirofiban
What are the Anticoagulants
Heparin Enoxaparin Dalteparin Tinzaparin Fondaparinux Leupirudin Bivalirudin Argatroban Warfarin
What are Thrombolytics used for
Tertiary Hemostasis
What do Thrombolytics activate
Plasmin
What are the Thrombolytics
Streptokinase Urokinase Alteplase Reteplase Tenecteplase Anistreplase
COX inhibitor
Aspirin
ADP receptor blockers
Clopidogrem
Ticlopidine
PDE inhibitors
Dipyridamole
Cilostazol
GPIIb/IIIa blockers
Abciximab
Eptifibatide
Tirofiban
Synthetic pentasaccharide
Fondaparinux
Direct thrombin inhibitors
Lepirudin
Bivalirudin
Argatroban
Coumarin Anti-coagulant
Warfarin
Made by beta-hemolytic strep
Streptokinase
Recombinant tPA
Alteplase
Purified human plasminogen with bacterial streptokinase
Anistreplase
Which clotting reducers are irreversible
Aspirin
Clopidogrel
Ticlopidine
Abciximab
What does Aspirin do
Block TXA2 - Prolong BT
What does TXA2 do
Increase affinity of GPIIb/IIIa for fibrinogen
When do you give Aspirin to stop clotting
Cerebral Ischemia
Stroke
MI
How long before new COX2 can be synthesized
10 days
How do ADP receptor blockers act
Inhibit P2Y12 receptor on platelets
When do you use ADP receptor blockers
Recent Stroke, MI, acute coronary syndrome
Why do you prefer Clopidogrel over Ticlopidine
Less AE
What do you NEVER give with Clopidogrel and why
Omeprazole (inactivates 2C19, 3A4)
ADP receptor blockers AE
Inhibit P450
Thrombocytopenic purpura
Which ADP receptor blockers can cause neutropenia
Ticlopidine