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Pharm Midterm 1 > Muscarinic Antagonists > Flashcards

Muscarinic Antagonists Flashcards

1
Q

Belladonna Alkaloids

A

Atropine

Scopolamine

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2
Q

QAC

A

Ipatropium
Tiotropium
Glycopyrrolate

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3
Q

Tertiary Amines

A 
Atropine
Scopolamine
Homatropine
Cyclopentolate
Topicamide
Beztropine
Trihexylphenidyl
Tolterodine
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4
Q

DOC motion sickness

A

Scopolamine

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5
Q

Decreases urinary hypermotility

A

Atropine

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6
Q

Bradycardia in low dose (pre M2)

Tachycardia in higher dose (atrial M2)

A

Atropine

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7
Q

CNS AE for muscarinic antagonists

A 
Hallucinations
Delirium
Depression
Restlessness
Confusion
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8
Q

DOC OD cholinergic

A

Atropine (farmer, insecticide)

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9
Q

Eye effects of Atropine

A

Mydriasis
Cycloplegia
Unreactive to light

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10
Q

GI effects of Atropine

A

Antispasmodic

Decrease motility

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11
Q

Sympathetic effects of atropine

A

Salivary, sweat, lacrimal secretions blocked

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12
Q

Blocks short term memory

A

Scopolamine

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13
Q

Bronchodilation and which receptor

A

Ipratropium
Tiotropium
M3

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14
Q

Shorter duration so use over Atropine

A

Homatropine
Cyclopentolate
Tropicamide

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15
Q

Action of Benztropine and Trihexyphenidyl

A

Restore balance input after loss of DAergic neurons in Substantia Nigra

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16
Q

SM relaxation

A

Tolteridine

17
Q

Decreases resp secretions prior to surgery

18
Q

Increase HR or Decrease AV block due to excessive vagal tone

19
Q

Use for death cap mushroom poisoning

20
Q

Stop muscarinic side effects of AchE drugs

21
Q

Inhaled

A

Ipratropium

Tiotropium

22
Q

Tx for COPD and asthma adjuvant

A

Ipratropium

Tiotropium

23
Q

Use for Parkinsonism or extrapyramidal effects (D2)

A

Beztropine

Trihexylphenidyl

24
Q

Prevent bradychardia in surgery

A

Glycopyrrolate (parenteral)

25
Q

Inhibit GI motility

A

Glycopyrrolate (oral)

26
Q

Used for overactive bladder

A

Tolterodine

27
Q

Atropine Flush

A

Cutaneous vasodilation

28
Q

Anti-PS AE muscarinic antagonists

A 
Xerstomia
Blurred vision
Sandy eyes
Tachycardia
Constipation
29
Q

Effect of muscarinic antagonists on glaucoma

A

Exacerbation

Blindness

30
Q

Effect of muscarinic antagonists on BPH

A

Decreased detrusor contraction

Urinary retention

31
Q

AE of low levels muscarinic antagonists

A

Bradychardia

Sedation

32
Q

AE of high levels muscarinic antagonists

A

Tachycardia

CNS hyperexcitation

33
Q

What amines can enter CNS

34
Q

Metabolism site of atropine

35
Q

Excretion site of atropine

36
Q

Longer duration in CNS than atropine

A

Scopolamine

37
Q

Cause Mydriasis and Cycloplegia

A

Homatropine
Cyclopentolate
Topicamide

Pharm Midterm 1 (36 decks)

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