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Pharm Midterm 1 > Histamine Antagonists > Flashcards

Histamine Antagonists Flashcards

1
Q

Physiological antagonist of histamine

A

Epinephrine

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2
Q

Mast cell stabilizers

A

Cromolyn

Nedocromil

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3
Q

1st gen H1 antagonists

A 
Chlorpheniramine
Diphenhydramine
Dimenhydrinate
Hydroxyzine
Promethazine
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4
Q

2nd gen H1 antagonists

A 
Fexofenadine
Terfenadine
Loratadine
Cetirizine
Astemizole
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5
Q

H2 antagonists

A

Cimetidine
Ranitidine
Famotidine
Nizatidine

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6
Q

Aside from mast cell stabilizers, what other category prevents degranulation

A

Beta 2 agonists

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7
Q

Which histamine antagonists cross BBB and cause sedation

A 
Chlorpheniramine
Diphenhydramine
Dimenhydrinate
Hydroxyzine
Promethazine
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8
Q

Why are 2nd gen less sedating than 1st gen

A

Less lipid soluble

Pumped out by P-glycoprotein

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9
Q

Does Epinephrine act on H receptor

A

No

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10
Q

Which histamine antagonists inhibit gastric acid secretion

A

Cimetidine
Ranitidine
Famotidine
Nizatidine

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11
Q

What is the term for H1 antagonists

A

Inverse agonists

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12
Q

What else do 1st gen block

A

Cholinergic
Alpha
5HT
Na+ channels (local anesthetic receptors)

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13
Q

DOC allergic rhinitis and urticaria and can be used for motion sickness

A

H1 antagonists

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14
Q

Tx for insomnia

A

H1 > H2

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15
Q

Used for PUD, acute stress ulcers and GERD

A

H2 antagonists

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16
Q

AE for 1st gen H1

A

Sedation

Dry mouth

17
Q

What can cause ventricular arrhythmia when combined with 3A4 inhibitors

A

Astemizole

Terfenadine

18
Q

What inhibits P450 and has strong anti-androgen effects

A

Cimetidine

Pharm Midterm 1 (36 decks)

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