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Pharm Midterm 1 > Direct Cholinergic Agonists > Flashcards

Direct Cholinergic Agonists Flashcards

1
Q

QACs

A

Acetylcholine
Bethanechol
Carbachol
Methacholine

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2
Q

Plant alkaloids

A

Muscarine
Arecoline
Pilocarpine
Nicotine

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3
Q

Bind M only

A

Bethanechol
Muscarine
Pilocarpine (partial)

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4
Q

Bind M and N

A

Acetylcholine
Carbachol
Methacholine
Arecoline

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5
Q

Bind N only

A

Nicotine (N > M)

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6
Q

Activates Bowel and Bladder

A

Bethanechol

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7
Q

Diagnosis of bronchial hyperactivity in asthma

A

Methacholine

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8
Q

Ganglion blocker in high dose

A

Nicotine

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9
Q

Can cause hypotension with rapid, weak pulse

A

Nicotine

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10
Q

No clinical uses

A

Muscarine

Arecoline

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11
Q

PS and S activity on sweat glands

A

Acetylcholine

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12
Q

M3 vasodilation and reflex tachy at low doses

Hypotension and brady at high doses

A

Acetylcholine

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13
Q

Miosis and contraction of ciliaris

A

Carbachol

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14
Q

Ciliaris contraction

Sweat, salivary, lacrimal, bronchial secretion

A

Pilocarpine

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15
Q

Tertiary amines

A

Pilocarpine

Nicotine

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16
Q

N effects of Acetylcholine

A

Stim autonomic ganglia
Epi secretion from medulla
Skeletal muscle - Increase HR, BP

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17
Q

Low dose nicotine effects

A

Ganglion depol (S + PS)
CVS - sympathomimetic
GI + UG - parasympathomimetic

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18
Q

Parasympathomimetic effects of nicotine

A

N/V/D, voiding, salivation, bronchial secretion

19
Q

High dose effects of nicotine

A

Ganglion blocker (prolonged depol)

20
Q

Smoking cessation therapy

A

Nicotine

21
Q

Acute close-angled glaucoma

A

Pilocarpine

22
Q

Full close angle glaucoma regimen

A 
Pilocarpine
Timolol
Apraclonidine
Acetazolamide
Mannitol or Glycerol
23
Q

Second line for open angle glaucoma

A

Pilocarpine

1st is timolol

24
Q

2nd line for close angle glaucoma

A

Carbachol (decrease intraocular pressure)

25
Q

Intraocular surgery

A

Carbachol

26
Q

Rapid miosis in cataract surgery

A

Acetylcholine

27
Q

Post surgical, postpartum urinary retention

A

Bethanechol

28
Q

Hypotonic/atonic, myogenic, neurogenic bladder

A

Bethanechol

29
Q

Ileus, gastroparesis, congenital megacolon

A

Bethanechol

30
Q

No CNS effects

A

Acetylcholine

31
Q

Makes acetate

A

Acetylcholine

32
Q

Makes Carbamate

A

Bechanechol

Carbachol

33
Q

Hydrolysis by AchE

A

Acetylcholine

34
Q

No hydrolysis by AchE

A

Bethanechol

Carbachol

35
Q

Cannot cross BBB

A

Bechanechol

36
Q

External use only

A

Carbachol

37
Q

Slow AchE hydrolysis

A

Methacholine

38
Q

Crosses placenta

A

Nicotine

39
Q

Highly liposoluble

A

Nicotine

40
Q

AE DUMBBELLSS

A

Acetylcholine
Bethanechol
Carbachol
Methacholine

41
Q

What is muscarinic syndrome

A 
Diarrhea	 
Urination	 
Miosis	 
Bradycardia	 
Bronchoconstriction	 
Emesis	 
Lacrimation	 
Lethargy	 
Salivation	 
Sweating
42
Q

CNS disturbances
Sweating
Salivation

A

Pilocarpine

43
Q

Effects of acute nicotine poisoning

A 
N/V/D
Salivation
Abdominal pain
Cold sweat
Confusion
44
Q

Death from resp arrest

A

Nicotine

Pharm Midterm 1 (36 decks)

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