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Pharm Midterm 1 > Alpha Antagonists > Flashcards

Alpha Antagonists Flashcards

1
Q

Acts nonselective on alpha

A

Phenoxybenzamine

Phentolamine

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2
Q

Selective for alpha 1

A

Prazosin
Terazosin
Doxazosin
Tamsulosin

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3
Q

Useful for HTN Tx

A

Prazosin
Terazosin
Doxazosin
Tamsulosin

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4
Q

Acts on alpha 2

A

Yohimbine

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5
Q

DOC pheochromocytoma

A

Phenozybenzamine

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6
Q

Reversible alpha blocker

A

Phentolamine

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7
Q

Irreversible alpha blocker

A

Phenoxybenzamine

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8
Q

Used for sudden clonidine withdrawal

A

Phentolamine

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9
Q

Tx for Tyramine with MAOI

A

Phentolamine

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10
Q

Anti-HTN in stimulant OD

A

Phentolamine

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11
Q

What receptors do Phenozybenxamine block/inhibit

A

H1
M
5HT
NET

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12
Q

What receptors do Phentolamine block/inhibit

A

5HT

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13
Q

What receptors do Phentolamine activate

A

H1, 2, M

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14
Q

CVS effects of Phenoxybenzamine

A

Prevent vasoconstriction
Reflex tachy
Increase CO

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15
Q

Phenoxybenzamine AE

A

Postural hypotention
Nasal stiffness
N/V
Inhibit ejaculation

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16
Q

Contraindication of Phenoxybenzamine

A

Decreased Coronary perfusion

17
Q

What is used for Dx and HTN crisis control of pheochromocytoma

A

Phentolamine

18
Q

What prevents dermal necrosis when NE extravasates

A

Phentolamine

19
Q

Contraindication of Phentolamine

A

Decreased Coronary perfusion

20
Q

Action of Prazosin

A

Decrease TPR (SM relax)

21
Q

What are Prazosin analogs with longer t1/2

A

Terazosin

Doxazosin

22
Q

Which alpha 1 blocker is selective for alpha1A in UG SM

A

Tamsulosin

23
Q

Which alpha 1 blocker decrease BP w/o reflex tachy

A

Prazosin
Terazosin
Doxazosin

24
Q

Which alpha 1 blocker decreases LDL/TAG and increases HDL

A

Prazosin
Terazosin
Doxazosin

25
Q

Tx of HTN and BPH

A

Prazosin
Terazosin
Doxazosin

26
Q

What treats BPH without affecting BP

A

Tamsulosin

27
Q

What can the first dose of alpha 1 blocker cause

A

Exaggerated hypotensive response and syncope

28
Q

AE for Phentolamine

A 
Postural hypotention (baro reflex and alpha 2 block)
Arrhythmia and angina
29
Q

Indirect adrenergic agonist

A

Yohimbine

30
Q

Causes NE release to increase BP

A

Yohimbine

31
Q

Tx erectile dysfunction (replaced by PDE-5i)

A

Yohimbine

32
Q

What do you not give Yohimbine with

A

Clonidine

Pharm Midterm 1 (36 decks)

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