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Pharm Midterm 1 > Pharmacogenomics > Flashcards

Pharmacogenomics Flashcards

1
Q

Drugs affected by BChE polymorphisms

A

Succinylcholine

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2
Q

Drugs affected by NAT2 polymorphisms

A

Hydralazine
Procainamide
Isoniazid

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3
Q

Drugs affected by 2D6 polymorphisms

A

Codeine among others

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4
Q

Drugs affected by thiopurine S-methyl-transferase polymorphisms

A

6-MP

Azathioprine

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5
Q

Drugs affected by EGFR polymorphisms

A

Gefitinib

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6
Q

Warfarin is affected by which polymorphisms

A

2C9

VKORC1 (Vit K epoxide reductase)

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7
Q

Drugs affected by G6PD deficiency (A-)

A

Primaquine (sulfonamides)

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8
Q

What happens in a BChE polymorphism

A

AR

Decreased rate of metabolism = longer paralysis

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9
Q

What is a normal Dibucaine number

A

> 75

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10
Q

What happens in NAT2 polymorphisms

A

Slow acetylators = increased drug levels (AR homo)

Fast acetylators = decreased drug levels

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11
Q

What happens in 2D6 polymorphisms

A 
Poor = Decreased codeine activation (AR homo)
Ultrarapid = Increased morphine effects (multiple copies)
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12
Q

What NAT2 drug can cause lupus

A

Hydralazine

Procainamide

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13
Q

What NAT2 drug can cause neuropathy and hepatotoxicity

A

Isoniazid

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14
Q

AE of poor 2D6

A

Ineffective dose

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15
Q

AE of ultrarapid 2D6

A

OD leading to resp depression

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16
Q

What happens in TPMT polymorphisms

A

Decreased activity

Only need 1/10 dose of drug

17
Q

What does TPMT do

A

Catalyses S-methylation of anti-CA thiopurines

18
Q

AE of giving std dose to TPMT polymorphism pt

A

Myelosupression

19
Q

What happens in EGFR polymorphisms

A

ATP binding site mutation

Enhances drug effect

20
Q

When is EGFR overexpressed

A

NSCLC

21
Q

What decreases metabolism of warfarin

A

2C9 polymorphism

22
Q

AE of 2C9 polymorphism

A

Increased hemorrhage risk

23
Q

AE of VKORC1 polymorphism

A

Hemorrhage and thrombosis

24
Q

What happens with a 90-95% reduction in G6PD

A

Decreased NADPH
Decreased glutathione
Increased H2O2

25
Q

What is G6PD deficiency protective for

A

Malaria

26
Q

G6PD exacerbation can lead to what

A

Hemolytic anemia

Pharm Midterm 1 (36 decks)

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