Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm Midterm 1 > Endogenous Catecholamines and D1 Agonists > Flashcards

Endogenous Catecholamines and D1 Agonists Flashcards

1
Q

What binds alpha and beta 2

A

Epinephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What binds alpha and beta 1 > 2

A

Norepinephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What binds D, alpha and beta

A

Dopamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What binds D1

A

Fenoldopam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

DOC for patients in anaphylactic

A

Epi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Potent vasopressor at high doses

A

Epi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Cause bradycardia

A

Norepi (indirect M2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Limited therapeutic value, but can treat shock

A

Norepi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

DOC for cardiogenic and hypovolemic shock

A

Dopamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Why is dopamine better than norepi for shock

A

DA preserves renal blood flow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Effects of high dose epi

A

Increase BP
+ve chronotropic/ionotropic (beta 1)
Vasoconstriction (alpha 1)
Increase CO and O2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Effects of low dose epi

A

Decrease PVR
Increase systolic, decrease diastolic
No change in MAP
Tachycardia (beta 1)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

SM effects of epi

A

Bronchodilation (beta 2)
Relax GI with contracted sphincters
Relax detrusor (beta 2), contract sphincter (alpha 1)
Prostate SM contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Metabolic effects of epi

A

Hyperglycemia

Lypolysis (beta 3)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How does epi cause hyperglycemia

A

Increase glycogenolysis and glucagon release (beta 2)

Net inhibition of insulin secretion (alpha 2 inhibits, beta 2 enhances)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What effect does epi have in glaucoma

A

Decrease aqueous humor production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

How do you treat asthma attacks with epi

A

Combine with local anesthetics to increase duration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Causes Vasoconstriction

A

Epi (alpha 1)

Norepi (alpha 1)

19
Q

Effects of norepi vasoconstriction

A

Increased PVR

Increased SBP/DBP and MAP

20
Q

Induces hyperglycemia less potent than epi

A

Norepi

21
Q

Function of DA

A

Central regulator of movement

22
Q

CVS effects of DA

A

Low dose - vasodilate (D1): renal, mesenteric, coronary

23
Q

How does DA treat shock

A

Increase GFR, RBF, Na+ excretion

Ie. preserves renal function

24
Q

What is the inotropic effect of DA

A 
Intermediate contraction (beta 1)
Increasing NE release
25
Q

Effect of DA on BP

A

Increase SBP

26
Q

Effect of high concentration DA

A

Alpha 1 vasoconstriction

27
Q

Effect of Fenoldopam

A

Peripheral vasodilation

28
Q

What is used for short term management of inpatient HTN

A

Fenoldopam

29
Q

Administration of Epinephrine

A

IV emergency

SC, ET tube, inhalation, topical eye

30
Q

Why don’t you give epi orally

A

Inactivation in gut

31
Q

Why is DA ineffective orally

A

Metabolized by MAO and COMT

32
Q

How is Fenoldopam administered

A

IV

33
Q

Does DA cross BBB

A

No

34
Q

Notable AE of epi

A

Tremor
ICH due to increased BP
Arrhythmias - Digitalis pts
Pulm edema

35
Q

What causes kidney shutdown

A

Norepi

36
Q

DA overdose

A

Sympathomimetic Sx

37
Q

Why is DA nausea, HTN and arrhythmia short-lived

A

Rapid metab to HVA

38
Q

Does Epi enter CNS

A

No, polar

39
Q

How is epi metabolized

A

COMT and MAO

Makes VMA and metanephrine

40
Q

How does hyperthyroid affect epi

A

Enhance CV actions

41
Q

How does cocaine affect epi

A

Prevent reuptake

42
Q

How do beta blockers affect epi

A

Cause predominate alpha effects - increase TPR and BP

43
Q

What counteracts local action of norepi

A

Baroreceptor reflex

44
Q

How do you block baroreceptor counteraction of norepi

A

Atropine

Pharm Midterm 1 (36 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions