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Pharm Midterm 1 > Indirect Cholinergic Agonists > Flashcards

Indirect Cholinergic Agonists Flashcards

1
Q

Dx for Myasthenia Gravis

A

Edrophonium

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2
Q

Tx for anticholinergic overdose

A

Physostigmine

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3
Q

Reversal of NMJ block by non-depol agents

A

Neostigmine

Edrophonium

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4
Q

Tx of Myasthenia Gravis

A

Pyridostigmine

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5
Q

Reversible AchE/Butylcholinesterase inhibitor

A

Edrophonium

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6
Q

Contraindicated in TCA overdose

A

Physostigmine

Aggravates cardiac conduction depression

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7
Q

Not Liposoluble

A

Echothiophate

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8
Q

Obsolete

A

Echothiophate

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9
Q

QAC

A

Edrophonium
Neostigmine
Pyridostigmine

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10
Q

Carbamate

A

Physostigmine
Neostigmine
Pyridostigmine

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11
Q

Covalent AchE/ButylChE inhibitor

A

Physostigmine
Neostigmine
Pyridostigmine

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12
Q

Does not enter CNS

A

Neostigmine

Pyridostigmine

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13
Q

Organophosphates

A 
Ecthiophate
Malathion
Parathion
Tabun
Sarin
Soman
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14
Q

Phosphorylate active site

A 
Ecthiophate
Malathion
Parathion
Tabun
Sarin
Soman
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15
Q

Aging to make reversal difficult

A 
Ecthiophate
Malathion
Parathion
Tabun
Sarin
Soman
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16
Q

Activated by conversion to O analogs

A

Malathion

Parathion

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17
Q

Nerve agents

A

Tabun
Sarin
Soman

18
Q

CNS effects of amines

A

Convulsion
Coma
Resp arrest

19
Q

PS effects of amines

A

Eye
Resp
GI
UG

20
Q

CVS effects of amines

A

Decrease CO and BP (hypotension)

21
Q

NMJ effects of amines

A

Increase contraction in weak muscles

22
Q

Used for intestinal or bladder atony

A

Physostigmine

23
Q

2nd line Myasthenia Gravis

A

Neostigmine

24
Q

Prevention and Tx of Urinary retention

A

Neostigmine

25
Q

Chronic open angle glaucoma

A

Echothiophate

26
Q

Insecticides

A

Malathion

Parathion

27
Q

Used for terrorism

A

Tabun
Sarin
Soman

28
Q

Used in Alzheimer’s

A

Tacrine
Donepezil
Rivastigmine
Galantamine

29
Q

Orally active

A

Tacrine
Donepezil
Rivastigmine
Galantamine

30
Q

Only lasts for 2-10min

A

Edrophonium

31
Q

Spontaneous hydrolysis (30min - 6hrs)

A

Physostigmine

Neostigmine

32
Q

Fully distributed organophosphates (enter CNS)

A 
Malathion
Parathion
Tabun
Sarin
Soman
33
Q

Tx for organophosphate overdose

A

Atropine

Pralidoximine

34
Q

CNS toxicity

A 
Pyridostigmine
Malathion
Parathion
Tabun
Sarin
Soman
35
Q

AE for Neostigmine

A 
N/D
Hypotension
Salivation
Flushing
Abdominal pain
Bronchospasm
36
Q

AE for Physostigmine (high dose)

A

Convulsions
SkM paralysis
Bradychardia

37
Q

Action of TCAs

A

Block Na+ channels

38
Q

Organophosphate poisoning Tx (before aging)

A

Pralidoxime

39
Q

When is Pralidoxime not used

A

Carbamate poisoning (reversible, short)

40
Q

Does Pralidoxine enter the CNS

A

No

Pharm Midterm 1 (36 decks)

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