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Pharm Midterm 1 > Pharmacokinetics > Flashcards

Pharmacokinetics Flashcards

1
Q

P450 Induction

A

Phenobarbitol
Phenytoin
Rifampin
Carbamazepine

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2
Q

P450 Inhibition

A

Cimetidine
Ketoconazole
Erythromycin
Chloramphenicol

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3
Q

Displaced from plasma protein

A

Warfarin

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4
Q

Overdose increases CYP2E1 metabolism

A

Acetaminophen

N-acetylcysteine

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5
Q

Toxic levels of NAPQ1 and reduced GSH

A

Acetaminophen

N-acetylcysteine

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6
Q

Effects of P450 Induction

A

Increase own metabolism
Increase metab of coadministered drug
Toxic metabolites

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7
Q

Effects of P450 Inhibition

A

Toxic drug concentrations

Prolong active drug presence

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8
Q

Adverse effect of warfarin

A 
Bleeding
Reduce absorption (interact with bile acid sequestrant)
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9
Q

Adverse effect of Acetaminophen

A

Liver failure

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Pharm Midterm 1 (36 decks)

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