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Pharm Midterm 1 > Anemia > Flashcards

Anemia Flashcards

1
Q

Used in Oral Fe therapy

A

Ferrous Sulfate
Ferrous Gluconate
Ferrous Fumarate

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2
Q

Used in Parenteral Fe therapy

A

Irondextran
Iron Sucrose
Na-Ferric gluconate

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3
Q

What are the Fe chelators

A

Deferoxamine

Deferasirox

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4
Q

What vitamins are used for anemia treatment

A

B12 - Cyanocobalamin, Hyroxycobalamin

B9 - Folate

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5
Q

What are the Hematopoetic GFs

A 
Erythropoietin
Darbopoietin
Filgrastim
Sargramostim
IL-11
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6
Q

What are the sickle cell agents

A

Hydroxyurea

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7
Q

What are oral Fe agents used for

A

Fe deficiency anemia

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8
Q

What are the AE for oral Fe agents

A

Constipation
Dark stool
Cramps
V/D

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9
Q

When can parenteral Fe agent toxicity occur

A

Young children by accident

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10
Q

When are parenteral Fe agents given

A

Oral not tolerated

Cannot be managed by oral alone

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11
Q

What are the AE for parenteral Fe agents

A

Acute Fe tox

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12
Q

What is seen in Acute Fe toxicity

A

Necrotizing gastroenteritis with vomitting, pain, bloody diarrhea
Shock, metab acidosis, coma, death

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13
Q

How is Acute Fe toxicity treated

A

Deferoxamine

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14
Q

When are Fe chelators used

A

Chronic Fe tox w/o anemia
Hemochromatosis
Multiple transfusions

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15
Q

How do Fe chelators work

A

Bind absorbed Fe

Promote excretion

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16
Q

What 2 reactions is B12 involved in

A

Homocysteine to methionine

Methl-malonyl to succinyl

17
Q

When is B12 given

A

Loss of IF

Malabsorption

18
Q

What can be given to partially correct B12 deficiency

A

B9

19
Q

What can B12 deficiency cause

A

Neuro abnormalities (increased homocysteine)

20
Q

What is B9 needed for

A

Purine synthesis

21
Q

What is required to form THF

A

B12

22
Q

How long does it take folate deficiency to develop

A

1-6 months

23
Q

Drug induced Folate deficiency

A

MTX
Trimethoprim
Pyrimethamine

24
Q

B9 AE

A

Mask neuro deficits in B12 deficiency

25
Q

When is erythropoietin made

A

Kidneys in hypoxia

26
Q

When is EPO administered

A

Anemia with renal disease

27
Q

What receptor process does EPO act

A

JAK/STAT

28
Q

3x longer acting than EPO

A

Darbopoietin

29
Q

When is Darbopoietin given

A

Chronic anemia with renal failure

Myelosuppresive chemo

30
Q

What acts through JAK/STAT

A

EPO
Filgrastim
Sargramostim

31
Q

What is involved in prolif and differentiation of PMNs

A

Filgrastim

Sargramostim

32
Q

What is given in neutropenia and chemo

A

Filgrastim

Sargramostim

33
Q

What allows for more platelets

A

IL-11

34
Q

When is IL-11 administered

A

Thrombocytopenia with chemo

35
Q

What does Hydroxyurea do

A

Increase HbF

36
Q

When is Hydroxyurea administered

A

Sickle cell anemia

37
Q

What are the AE for Hydroxyurea

A

BM suppression

Cutaneous vasculitis

Pharm Midterm 1 (36 decks)

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