Presynaptic Adrenergic Antagonists Flashcards
1
Q
What inhibits tyrosine hydroxylase
A
Alpha-methyltyrosine (Metyrosine)
2
Q
What causes irreversible damage to VMAT
A
Reserpine
3
Q
What does Metyrosine do
A
Block NE and E synthesis
4
Q
When do you use Metyrosine
A
Adjuvant with Phenoxybenzamine for pheochromoytoma
5
Q
What does Reserpine do
A
Decrease NE and DA availability
6
Q
When do you use Reserpine
A
Excess breakdown of catecholamines by MAO
Decreased BP and HR
7
Q
Which was once used for HTN Tx
A
Reserpine
8
Q
What does Guanethidine do
A
Displace NE in storage vesicle to deplete it
Disrupts release of NE from nerve terminal
9
Q
How does Guanethidine get into the nerve terminal
A
NET uptake
10
Q
What was Guanethidine used for
A
Anti-HTN
11
Q
AE of Guanethidine
A
Orthostatic Hypotension
Male sexual dysfunction
