Bleeding Flashcards
Which is a tPA inhibitor
Aminocaproic acid
Which are antidotes for bleeding due to drugs
Protamine sulfate
Vit K
Plasma fractions
What does Aminocaproic acid do
Inhibit fibrinolysis
How does Aminocaproic acid work
Inhibit plasminogen activaition
When do you give Aminocaproic acid
Hemophilia
Bleeding in fibrinolytic therapy
Aneurysm bleeding
Post-surgery GI bleed
When do you NOT use Aminocaproid acid
DIC
Upper GI bleed
What can Aminocaproic acid cause
Intravascular thrombosis
HTN, myopathy
Abdominal dyscomfort, diarrhea
Nasal stuffiness
What does Protamine sulfate do
Chemical antagonist of heparin
What does Protamine sulfate NOT work against
Fondaparinux
When is Protamine sulfate used
Heparin Toxicity (UFH)
What are the AE of Protamine sulfate
Coagulation if no heparin
Dyspnea, flushing, bradycardia, hypotension
What does Vit K do
Carboxylates clotting factors
How fast does Vit K act
Onset - 6hrs
Complete - 24hrs
What is used in immediate hemostasis
Fresh-frozen plasma
When do you give Vit K
Stops Warfarin bleeding
Hypoprothrombinemia in babies
