RBC Physiology Flashcards

1
Q

Function of RBC

A

Carry O2 from lungs to tissue and trasport CO2 from tissue to lungs and buffer H+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Uniquie RBC properties

A

-Flexibility
-Strength
-Shape-> increased surface area
-Hemoglobin
-Lifespan-> short

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Deformability of RBC

A

-Structure of membrane and cytoskeleton
-High surface area to volume ratio
-Low viscosity cytoplasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

RBC life span

A

Relatively short
-Horses have the longest with cats and dogs on the lower end

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Time for Erythropoiesis

A

5-7 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What stimulates erythropoiesis

A

Erythropoietin, produced from the kidney, stimulates stem cells in the bone marrow (spleen is minor) to erythroid precursors and continues to stimulate them to induce maturation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What triggers erythropoietin release

A

Hypoxia in the tissues (renal hypoxia specifically)
-Anemia
-Poor renal perfusion
-Poor oxygenation of blood (altitude)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

High EPO

A

Erythroid hyperplasia
-Shortened maturation time
-Accelerated release of reticulocytes
-increased Hgb synthesis in dividing cells
-Decreased apoptosis of progenitor cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Persistently low EPO

A

Erythroid hypoplasia
-Gradual onset of anemia
Could be from decreased functional renal tissue or inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Iron on erythropoiesis

A

A deficiency in iron results in anemia due to impaired RBC production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Irons role in RBC

A

At center of heme molecule is Fe2+ which is what reversibly binds oxygen and this Hgb concentration is the rate limiting step in erythropoiesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MetHgb

A

Oxidized form (Fe3+) and lacks the electron pairs for O2 to bind

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CO and Hgb

A

Has a higher affinity to bind to Hgb than O2 and will displace

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Ferritin

A

Rapidly mobilized iron pool (KSU is the only lab that can measure this)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Hemosiderin

A

Stable form of stored iron, aggregate of denatured ferritin and less readily available

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Heme synthesis

A

Occurs in RBC precursors and they need a mitochondria with AA synthase as a rate limiting enzyme and needs vitamin B

17
Q

Senescent RBC

A

Taken up by macrophages usually in the spleen and Hgb is degraded

18
Q

What happens to heme when RBC debraded

A

Made into bilirubin and then gets into the blood and bind to albumin until the liver-> Bu will leave the Alb and enters hepatocyte and binds to proteins to prevent from leaving-> now becomes conjugated to glucuronic acid (most species)-> enters canaliculus and into intestine-> bacterial degradation to Urobilinogen and recycled or degraded into stercobilinogen and excreted