Mechanisms of polyuria

Question 1

Lack of ADH

Answer 1

Central diabetes insipidus
Psychogenic polydipsia

Question 2

Distal tubule/collecting duct lack of responsiveness

Answer 2

Nephrogenic diabetes insipidus

Question 3

Lack of concentration gradient between tubular fluid and interstitium

Answer 3

-Solute diuresis
-Reduced medullary interstitium osmolality

Question 4

Solute diuresis

Answer 4

-When kidneys are functioning normally but presented with increased solute (diabetes mellitus)
-Decreased number of functional nephrons and as result increased solute load on functioning nephrons