Mechanisms of Neutropenia

Question 1

Severe, overwhelming, acute inflammation

Answer 1

Neutropenia occurs because migration of neutrophils to tissue exceeds the release from the marrow. Cytokines from inflammatory site cause really high migration to tissue, will see left shift because release from storage and maturation pool

Question 2

Gram negative infection neutropenia

Answer 2

Endotoxins stimulate sequestration of neutrophils in the marginating pool and shift from circulating to marginating pool. There is a release of storage and maturation pools

Question 3

Granulocytic hypoplasia neutropenia

Answer 3

Marrow cells or cell environment is damaged. Causes a decreased granulopoiesis. There is persistent neutropenia but no left shift because maturation is still orderly but just less produced. Often see other cell types affected

Question 4

Ineffective production neutropenia

Answer 4

Disease causing ineffective granulopoiesis which causes a lack of orderly and complete maturation and get maturation arrest and those cells die and are not being released

Question 5

Peripheral destruction neutropenia

Answer 5

No chemotactic stimuli, but they are being removed from the blood (immune mediate or hemophagocytic syndrome) may or may not be able to keep up and release storage and maturation pools