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Rats Flashcards

1
Q

Genus species of rats most commonly used for research

A

Rattus norvegicus (Brown Norway Rat)

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2
Q

T or F. Rats do not have a gallbladder

A

T

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3
Q

How many pairs of mammary glands to rats have?

A

6

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4
Q

What laboratory animal species lack haversian canals in their bones?

A

Rats, mice and hamsters

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5
Q

What is the range of appropriate light intensity at the cage level for rats?

A

130-325lux

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6
Q

Which mutant strain of rat is a model for Diabetes insipidus?

A

Brattleboro

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7
Q

What is the unique characteristic of the Gunn rat

A

-jaundice, kernicterus

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8
Q

What is the the Zucker rat used to study?

A

obesity

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9
Q

Which rat strain is used for National Tox Program’s Carcinogen Bioassay

A

Fischer 344

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10
Q

Which inbred strain is useful as a model of autoimmune thyroiditis

A

Buffalo

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11
Q

What is the Lewis rat commonly used to study?

A

multiple sclerosis and other autoimmune disease

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12
Q

In what type of research is the SHR inbred strain of rat used?

A

spontaneous hypertensive rat

cardiovascular disease and hypertension research

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13
Q

What are the 2 most commonly used outbred

stocks of rats.

A

Sprague-dawley

Wistar

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14
Q

Is the harderian gland located medial or lateral to the orbit?

A

medial

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15
Q

What is the term used to describe excessive secretions of the Hardarian gland

A

Chromodacryorrhea

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16
Q

Name a frequently used purified diet for rats

A

AIN-76

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17
Q

What is the diploid number of chromosomes for Rats

A

42

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18
Q

What is the etiologic agent of Pseudotuberculosis in a rat

A 
Corynebacterium kutscheri (gram positive)
-abscesses in the lungs, liver, kidneys, skin jones
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19
Q

What is the hallmark lesion of Tizzer’s disease in the rat

A

coagulative necrosis of the liver

20
Q

What is the etiologic agent of rat-bite fever?

A

Streptobacillus moniliformis (gram neg bacillus)
non pathogenic in rats
rare in modern rat colonies

21
Q

Cilia-associated Respiratory Bacillus (CAR bacillus) are classified as what type of bacteria

A

“gliding

22
Q

What are common clinical signs of CAR bacillus in rats?

A

usually asymptomatic

23
Q

What is the classic lesion of Mycoplasma pulmonis infection in adult rats (which is rarely seen these days)

A

“cobblestone” lung

24
Q

What is the etiologic agent of Hemobartonellosis in a rat

A

Mycoplasma haemomuris

-gram negative bacteria that parasites rat erythrocytes

25
Q

How is M haemomuris transmitted

A

by the spiny rat louse

26
Q

Give the genus and species of the spiny rat louse

A

polyplax spinulosa

27
Q

To what family does Sendai virus belong?

RNA or DNA

A

Paramyxoviridae

RNA

28
Q

T or F. Sendai virus has a similar presentation in rats as mice

A

F. It is asymptomatic and self limiting in Rats

29
Q

Name the 2 prototypic coronaviruses of rats

A

Parker’s Rat corona virus (RCV-P)
Sialodacryoadenitis virus (RCV-SDA)
(neutralizing antibody to one prototype, will not offer cross protection from the other)
-enveloped RNA

30
Q

Name the parvoviruses that infect rats

A

RV- rat virus (Kilham’s rat virus)
H-1 virus (Toolan’s)
RPV-Rat parvovirus
RMV- rat minute virus

31
Q

List some characteristic of parvoviruses in general

A

single stranded DNA virus

-infect rapidly dividing cells

32
Q

What is the inclusive species name that now includes all the mouse and rat parvoviruses

A

Rodent protoparvovirus 1

33
Q

T or F. RV has a tropism for T-cell lymphocytes

34
Q

What is the family and characteristics of hantavirus?

A

genus- hantavirus, family bunyviridae

-enveloped RNA

35
Q

For which Hantavirus is Rattus norvegicus natural host?

A

Seoul Hantavirus- agent of Hemorrhagic fever with renal syndrome (HFRS) in humans

36
Q

What is the most common oxyurid of the rat?

A

Syphacia muris

37
Q

What are the most common clinical signs and pathology associated with Syphacia muris in the Rat

38
Q

What tissue/organ does the nematode Trichosomoides crassicauda inhabit in the rat?

A

Urinary bladder

39
Q

Name the fur mite most likely to be encountered in rats

A

Radfordia ensifera

40
Q

How is Pneumocystis carnii transmitted to rats

A

airborne transmission

or possible through soiled bedding

41
Q

What is the hallmark histologic lesion noted in the lungs of rats infected with Pneumocystis carny

A

perivascular lymphocytic cuffing

42
Q

Which strain of rat has a high incidence (near 100%) at 3-4months of age of eosinophilic granulomatous pulmonary inflammation, with no determined etiology?

A

Brown Norway

43
Q

Which strains of rat are prone the polyarteritis?

A

Sprague-Dawley and SHR

44
Q

Which strain of rat is mostly likely to have a testicular tumor, and what type of tumor will it likely be?

A

F-344

interstitial cell

45
Q

What type of pituitary tumors are most common aged rats?

A

chromophobe adenoma

46
Q

What strain of rat is likely to have a large granular lymphocytic leukemia?

A

F-344

  • initial site of malignancy is spleen
  • splenomegaly common

ACLAM (32 decks)

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