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ACLAM > Comp Med 2015 (All issues) random questions > Flashcards

Comp Med 2015 (All issues) random questions Flashcards

1
Q

genus species of gold fish

A

Carassius auratus

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2
Q

genus species of the fish lice

A

Argulus japonicus

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3
Q

Fish lice can be the vehicle for what other fish pathogens

A

Rhabdovirus carpio, Saprolegnia

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4
Q

T or F

Mice have smaller erythrocytes with shorter lifespan than most other species

A

T

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5
Q

T or F

Ringworm nuclear morphology is a normal feature of mice neutrophils, eosinophils and monocytes

A

T

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6
Q

T or F

Mice have very high platelet counts compared to other mammals

A

T
900,000 to 1.6million/imcroliter
-5d lifespan, shorter than most species

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7
Q

T or F

Bone marrow cellularity for mice is higher than most other species and does not decrease with age

A

T

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8
Q

What is the primary site for iron storage in mice

A

Spleen

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9
Q

T or F

The spleen remains an active site for hematopoeisis in mice throughout life

A

T

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10
Q

What is the recommended maximal amount of blood that can be collected from mice, with a 4-wk recovery period?

A

15%

-average blood volume is 7.8ml/100g.

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11
Q

What is the predominant leukocyte of most healthy wild type strains of mice?

A

lymphocytes

70-80% of the diff count

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12
Q 
T or F
Mouse neutrophils (and other granulocytes) may have the unique feature of ringworm or figure 8 nuclei?
A

T…picture of such in review article

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13
Q

Is mouse norovirus an RNA or DNA virus?

A

RNA- ss

Caliciviridae

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14
Q

What is the cellular tropism for infection by MNV

A

macrophages and dendritic cells

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15
Q

T or F

MNV has been shown to increase macrophage content of atherosclerotic lesions in LDLr-/- mice fed an atherogenic diet

A

T

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16
Q

What are myD88 mice deficient in?

A

Myeloid differentiation factor 88

used immunological research as models of IBD and diabetes

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17
Q

What species of hamster has the most compressed reproductive cycle of any placental animals?

A

Phodopus sungorus

aka- siberian dwarf or djungarian hamster

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18
Q

genus species of the big brown bat

A

Eptesicus cuscus

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19
Q

What pathogen is thought to be the cause of white-nose syndrome in bats

A

Pseudogymnoascus destructans

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20
Q

What tissue expresses corticotrophin releasing hormone in humans and anthropoid primates?

A

Placenta

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21
Q

What are the common sources of gamma-irradiaters in use

A

137CS and 60Co
Regulated by the US Nuclear Regulatory Commission
require people with access to have background check and fingerprinting

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22
Q

Name the novel species of Streptococcus was identified in weanling C57BL/6 mice presenting with running and neurologic signs

A

Streptococcus azizii

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23
Q

What agent may be added to the drinking water of mice to induce IBD and dehydration?

A

DSS dextran sulfate sodium

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24
Q

What is OCT (optical coherence tomography)

A

an imaging technique that used a thin wire and NEAR infrared to capture micrometer resolution from tissue

25
Q

What was Respiratory Inductance Plethsmoraphy used to measure in swine

A

Tidal volume

measures amplitude changes in ribcage and abdomen movements and correlates to tidal volume

26
Q

T or F

Squirrel monkeys are some of the most susceptible NHP species for experimental infection with CJD

A

T

27
Q

T or F

Squirrel monkeys have been used for vaccine development for HTLV

A

T

28
Q

What type of virus is SaVH1, for which squirrel monkeys are the natural host

A

alpha herpes virus
Saimiriine herpesvirus 1 (aka herpesvirus tamarinus)
90% seroprevalence in squirrel monkeys

29
Q

How many cases of human infection with SaHV1 have been reported?

A

none,

not believed to be zoonotic

30
Q

How is SaVH2 classified?

A

gamma herpes virus
Saimiriine herpesvirus 2 (aka herpesvirus saimiri or HVS)
closely related to Kaposis sarcoma virus (human herpes virus 8)

31
Q

What is the cellular tropism of SaHv2

A

T cells

know to cause lymphomas and t-cell leukemia in other neotrop species (but not squirrels)

32
Q

What category herpesvirus is SaHV3

A

gamma
lymphcryptovirus
most similar to EBV in humans

33
Q

What category herpesvirus is SaHV4

A

betaherpes
Saimiriine herpes virus 4
Squirrel monkey cytomegalovirus

34
Q

What is the pathology caused by Squirrel monkey polyomavirus (SMPyV)

A

not know to be pathogenic in the host species

route of transmission unknown

35
Q

To what viral genus dos Squirrel monkey retrovirus belong (SMRV)

A

betaretrovirus

type D retrovirus

36
Q

To what viral genus does Simian foamy virus belong?

A

Spumavirus
retrovirus
no known pathology in host or other species
cytoxic in cell culture causing big vacuoles (hence the name foamy virus)

37
Q

What is the likely natural host for Marburg virus

A

Egyptian fruit bat (Rousettes aegyptiacus)

38
Q

omega 3 and omega 6 fatty acids are categorized as poly or mono unsaturated fatty acids

A

poly- PUFA

39
Q

T or F

High intake of omega 6 PUFA may promote inflammation resulting in chronic inflammatory disease

A

T

appropriate dietary intakes for PUFA have not been established for most species

40
Q

T or F

Warm water fish species (zebrafish) require both omega 3 and omega 6 PUFA

A

T

Cold water species have a higher requirement for omega 3

41
Q

ErbB2tg mouse was recently used and characterized as a model for what human disease?

A

Hypertrophic cardiomyopathy

  • cardiac ErbB2tg receptor tyrosine kinase over expression
  • similar gross and ECG abnormalities as humans with HCM- prolonged QT intervals, wide QRS completes, high P and R
42
Q

genus species of cotton rat

A

Sigmodon hispidus

43
Q

The cotton rat is the preferred model for what common human virus causing upper airway infection, especially in young children?

A

RSV- respiratory syncytial virus

paramyxovirus-neg sense RNA

44
Q

What is the etiology of hepatosis dietetica in swine

A

vitamin E-selenium deficiency in growing pigs

45
Q

What are the 2 most commonly used mouse models of atherosclerosis?

A

mice deficient in ApoE or LDLr
ApoE-/- or LDL-/-
-both have impaired lipoprotein production and metabolism
-LDLr-/- must consume a high fat, hight cholesterol diet to become atherogenic, ApoE-/- will develop athero spontaneously

46
Q

Is mouse norovirus a DNA or RNA virus

A

RNA, non enveloped

calicivirus

47
Q

What is the cellular tropism for MNV

A

dendritic cells and macrophages (and b cells)

48
Q

What gland produces melatonin. Are levels higher or lower at night?

A

pineal

higher levels at night

49
Q

T or F

Night time shift work has been shown to increase the risk of prostate cancer in men.

A

T

50
Q

What are struvite crystals composed of?

A

magnesium ammonium phosphate

aka triple phosphate

51
Q

according to a recent article what strain of Rats are likely predisposed to development of urolithiasis

A

Long evans

outbred

52
Q

What is the etiologic agent of Epizootic Catarrhal enteritis in ferrets

A

ferret enteric Coronavirus

53
Q

What type of virus (RNA or DNA) is responsible for Ferret Systemic Coronavirus (FRSCV) associated disease

A

RNA

54
Q

What are the common clinical signs associated with Ferret Systemic Coronavirus?

A

anorexia, weight loss, diarrhea, abdominal mass

-pyogranulomatous to granulomatous inflammation of multiple organs

55
Q

T or F
One of the histological lesions associated with Ferret Systemic Corona virus may be cholesterol clefts in close association with multinucleate giant cells

A

T

56
Q

What other common ferret viral disease is a necessary differential for Ferret Systemic Coronavirus, and how are they differentiated

A

Aleutian disease (parvovirus)

  • can be diagnosed by PCR
  • FRSCV- can be diagnosed by serology/immunohistochem with FIPV3-70antibody
  • Aleutian disease is likely to also show hypergammaglobulinemia
57
Q

List 3 modes of injection that are used to produce a model on intracerbral hemorrhage dogs

A

balloon inflation
blood injection
bacterial collagenase-preferred because it mimics hematoma expansion

58
Q

Name a bacterial growth agar that is selective for Yersenia

A

Cefsulodin-irgasan-novobiocin

ACLAM (32 decks)

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