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ACLAM > JAALAS Nov 2016 random questions > Flashcards

JAALAS Nov 2016 random questions Flashcards

1
Q

T or F
Brief isoflurane anesthesia for oral gavage dosing in mice showed no evidence of greater stress than oral dosing awake mice

A

T

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2
Q

What has been the acceptable standard of RLUs in santiziationn of laboratory animal settings

A

1000RLUs

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3
Q

T or F

EAD sampling using PCR is sensitive even when disease prevalence is low

A

T

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4
Q

How often should enclosures and accessories (tops) be sanitized according to the guide?

A

at least once every 2 weeks

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5
Q

The dose of Dexmeditomidine required to achieve the equivalent effect of Meditomidine is 1/2 as much or 2x as much?

A

1/2 the dose of Dexmeditomidine is required

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6
Q

What does the term “piping” refer to in zebra fish

A

gasping for air at the water surface

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7
Q

T or F.
A recent study in JAALAS 2016 determined that neither bacterial growth or ATP concentration differed significantly between 1 and 4 weeks of use (in mice housing)

A

T

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8
Q

This recent study shows that BALB/c mice euthanized by slow filled CO2 chamber develop severe pulmonary hemorrhage

A

This may need to be refined in a balb/c study with pulmonary pathology as an endpoint

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9
Q

genus sp of Sooty Mangaby

A

Cercocebus atys

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10
Q

T or F European rabbits are know to live in social groups with dominate male and several subordinate males and females

A

T

this is unique to european rabbits

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11
Q

T or F

Lidocaine has the same mechanism of action as MS222

A

T

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12
Q

Traditional cryopreservation medias contain egg yolks extenders to aid with preservation. What is the risk of using hen egg yolk for preservation of sperm

A

potential pathogens- viruses (influenza), fungus

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13
Q

T or F.
Administration of Ketamine xylazine cocktail by SC route can be effective for surgical anesthesia in some strains and sexes of mice

A

T

this article determined it to be safe and effective, but may need some refinement of appropriate dose per strain and sex

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14
Q

Ketamine inhibits/activates N-methyl-D-aspartate receptors

A

inhibits

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15
Q

What is the most reliable and sensitive test method to detect Pasteruella pneumotropica?

A

PCR

serology unreliable, mass spect too expensive

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16
Q

T or F. Acarus siro are visible to the naked eye

A

F.

The grain mite is generally not visible to the naked eye (o.5mm) compared to the book lice (3mm)

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17
Q

What units are used to express the amount of ATP measured by the luminometer.

A

Relative light units (RLU)

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18
Q

T or f
IVC exhaust sampling reliably detected pathogens that are difficult to detect by traditional sentinel housing, and detected pathogens weeks after the onset of pathogen detection

A

T

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19
Q

Is xylazine a alpha-2 agonist or antagonist?

A

agonist

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20
Q

What component in egg yolk is thought to aid with cryopreservation of sperm

A

LDL

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21
Q

Buprenorphine is 25-50 times more/less potent than morphine

A

more

22
Q

Buprenorphine is a partial agonist at the ____ receptor and antagonist at the ___ receptor

A

mu

kappa

23
Q

T or F

C57BL/6 express Klra genes?

A

F

Klra genes are part of the NK cell that help with antigen presentation, 129 and C3H strains do express them

24
Q

genus species of the commonly use european rabbit

A

Orytolagus cuniculus

25
Q

Glucocorticoid levels in the hair is an indicator of chronic or acute stress?

A

chronic

26
Q

T or F. Mouse norovirus is persistently shed in the feces

A

T

as opposed to MHV ad MPV which are shed transient

27
Q

C57BL/6 predominately develop a Th1 or Th2 response

Balb/C predominately develop a Th1 or Th2 response

A

C57- Th1

BALBc- Th2

28
Q

What is the product produced by flour beetles (Tribolium sp ) that renders and unpleasant oder and may induce tumor incidences in swiss albino mice

A

Benzoquinone

29
Q

T or F. Wild rabbits tend to socialize in groups of 4-6

A

F

They tend to socialize in groups of 3 or less

30
Q

T or F. Rabbits are a crepuscular species

A

T

31
Q

T or F. Sooty Mangaby troops are typically multimale-multifemale with a matrilineal dominance structure

A

T

Though less nepotistic than macaques or baboons

32
Q

Submissive acts between rabbits often
include retreating when a dominant buck approaches. A safety distance of ___m seems to be the the observed minimal safety distance to demonstrate submission

A

1m

33
Q

Current guidelines recommend CO2 euthanasia using what percentage air displacement rate per minute

A

10-30%

And do not recommend placing conscious animals in a pre-filled chamber

34
Q

What is the most common chemical agent for euthanizing zebrafish. How?

A

MS222

Dipolarizes sodium channels rendering unconsciousness, vascular collapse and death due to hypoxia

35
Q

T or F.

Sanitization consists of cleaning and disinfection

A

T

cleaning removes organic debris and disinfection then reduces the concentration of microbes

36
Q

Name a dissociative anesthetic that produces catalepsy .

A

ketamine

37
Q

T or F.

Dexmeditomidine is the dextroisomer of medetomidine

A

T

38
Q

What is the accepted date after birth when rats are considered adult?

A

60d

39
Q

What does the Randal-Selitto test measure?

A

Withdrawal response to pressure applied by an algeisometer

http://www.iitcinc.com/images/Randall-Seilto_new.jpg

40
Q

What does EAD stand for in relation the environmental sampling of IVC units

A

Exhaust air duct sampling

41
Q

Does Dexmeditomidine reduce or increases cerebral blood flow?

A

Reduces it

Through alpha-2 receptor mediated vasoconstriction

42
Q

T or F

Neither lidocaine nor MS222 are effective at euthanizing zebrafish less than 16dpf

A

T

According to this recent study

43
Q

Free ranging rabbits maintain an interindividual distance of how may meters during daytime actives

A

15-20m

suggesting even social groups require a lot of space

44
Q

Polyplax spinulosa is the vector for what common laboratory animal pathogen

A

Mycoplasma haemomuris

45
Q

A multientranced burrow system in which rabbits dwell is called a ______

A

warren

46
Q

Genus sp of booklice
Genus sp of grain Mites
Genus sp of Flour Beetles

A

Liposcelis spp
Acarus siro
Tribolium sp.

47
Q

T or F

larval stage zebra fish use gills more than skin for respiration

A

F. They use skin more than gills, which effects how chemical euthanasia agents (lidocaine and MS222) work in larva vs adults

48
Q

T or F. A recent study indicates that lidocaine hydrochloride was effective for euthanasia of adult zebrafish

A

T

And produced it more rapidly than did MS222

49
Q

Flour beetles can be an intermediate host for what laboratory animal pathogen known to infect rats, mice, humans and other primates, albeit rare.

A

Hymenolepis dimunata

50
Q

T or F. The size of a group and warren is related to the amount of “cover” present, since that is the rabbits main defense against predators

A

T.
If cover is plenty, rabbits may diverse themselves, and breeding females may not share burrows and instead isolate themselves

ACLAM (32 decks)

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