JAALASJuly 2016 Random Flashcards
The elevated plus maze is used to test for anxiety-like behavior or spatial memory?
anxiety-like behavior
What behavior does the marble burying test measure
neophobia, anxiety and repetitive behavior
records the number of marbles buried in a specific amount of time
How can ES cell contribution to offspring be assessed visually?
by coat color
The AVMA guideline on euthanasia recommends that “___” species should not be present when individual animal euthanasia is performed
“sensitive” species
A recent study concluded that mice exposed to euthanasia of other animals by CO2 or decaptiation did had no noticeable affect.
They did however respond to the noise of the guillotine, whether and animal was being euthanized or not.
Genus and species of Deer mice
Peromyscus maniculatus
Are deer mice nocturnal or diurnal?
nocturnal
According to this recent study which substrate seems to be ideal for deer mice nest building?
brown crinkled paper
What is the mechanism of action of alfaxalone
GABA receptor binderWh
Describe myoclonic jerk
leg twitching behavior associated with administration of alfaxalone to mice
large amplitude rhythmic movement
genus and species of the goat
Capra hircus
T or F.
Compared to sheep goats are considered more sensitive to pain
T
What is the mechanism of action of local anesthetics, such as lidocaine?
sodium channel inhibition, preventing nerve conduction in pain fiber (A,delta, c)
This recent study concluded that CRI lidocaine improved analgesia with no cardiopulmonary effect in goats
T
T or F
Cefovecin has similar pharmacokinetics in dogs and NHPs
F
They are vastly different and for that reason cefovecin is no recommended for use in NHPs
T or F
Transdermal fentanyl solution has been approved for use in dogs
T
Name the reversal agent for Fentanyl
Naloxone
a pure opiate antagonist
To which receptor sites does Naloxone bind?
mu, kappa and delta, highest affinity for mu
A recent publications suggest that transdermal fentanyl is not recommended for use in NHPs
T
Due to unreliable pharmacokinetics in NHPs (neither the patch nor solution were recommended)
What is the most common method of collection of genetic material from mice for genotyping
tail biopsy
t or f
A recent publication recommends the use of ice-cold ethanol prior to tail biopsy in mice 7-15d of age
T
What is the acceptable displacement volume of CO2 to use for rodent anesthesia
10-30% per minute
A recent publication demonstrated a lack of significant effects on physiological, behavioral or histological parameters whether the acceptable flow rate of 10-30% or a much higher chamber displacement rate was used
questioning whether the AVMA guideline rate or a much higher rate is more humane
What is the likely contributor of ulcerative dermatitis in C57BL6 mice or those on a B6 background?
Th-1 driven immune response
According to a recent article, what is the recommended treatment for ulcerative dermatitis?
nail trimming
Genus species, family and order of guinea pig
Cavia porcellus, Caviidae, Rodentia
T or F
Guinea pigs are born with their eyes open?
T
What does the term paurangiotic refer to in the Guinea pig eye
blood vessels occur only near the optic disc
Do guinea pigs have a third eyelid to protect the cornea?
no it is vestigial
Also GPs blink only 2-5times every 20 min! They have pronounced tear film stability
What are the most common bacterial pathogens associated the conjunctivitis in the GP
Chlamoydophila psittaci and caviar
T or F
Tritrichomonas muris is a highly transmissible agent that occurs in the GI tract of mice
T
typically it is non-pathogenic, but may cause disease in immunocompromised mice
T or F
Ronidazole is an antiparasiticide that my be useful in controlling Tritrichomonas muris in mice
T
What is the primary mechanism of action of isoflurane
activation of gamma-aminobutyric acid channels, which increases chloride permeability of neurons
genus species of ferret
Mustela putorius furo
genus species of Sooty mangabeys
Cercocebus tays
T or F
HCT can affect the accuracy of hand-held glucometers in humans
T
T or F
Handheld glucometers are less accurate in the state of hypoglycemia
T
Does arterial or venus blood generally have higher glucose levels
Arterial
A recent article concludes that human or veterinary hand held glucometers are likely more accurate in NHPs?
human
HCT, sampling site, physiologic state might also have an effect on glucose accuracy
