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ACLAM > Animal Models BB Chap 34 > Flashcards

Animal Models BB Chap 34 Flashcards

1
Q
  1. Many-to-many modeling (as opposed to one-to-one modeling) is best described as analyzing a process at several hierarchical levels. All of the following are common examples of diseases employing many-to-many models except:
    a. obesity
    b. cancer
    c. spontaneous monogenetic disorders
    d. diabetes
A

c

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2
Q
  1. Induced models are typically developed by the following methods except:
    a. surgical manipulation
    b. genetic manipulation
    c. spontaneous genetic mutation
    d. chemical induction
A

c

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3
Q
  1. Induced models are typically developed by the following methods except:
    a. surgical manipulation
    b. genetic manipulation
    c. spontaneous genetic mutation
    d. chemical induction
A

a

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4
Q

The watanabe rabbit is a spontaneous model for what disorder:

a. Digeorge syndrome
b. hypercholesterolemia
c. autoimmune thyroiditis
d. ichtyosis congenital
A

b

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5
Q
  1. Streptozotocin and Alloxan are commonly used agents to induce animal models for which of the following disease:
    a. SHR- primary hypertension
    b. atherosclerosis
    c. insulin-dependent diabetes
    d. cancer
A

c

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6
Q

Chickens with Beriberi resulted in a cure for humans (and animals) of what vitamin deficiency?

A

thiamine

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7
Q
  1. hu-SCID mice (severe combined immune deficient mice with human lymphocytes or stem cells) serve as an excellent small animal model for the assessment of anti-HIV drugs. T or F
A

T

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8
Q

ENU (N-nitroso-N-ethylurea) is a chemical mutagen that causes very specific single base mutations. T or F

A

F- the mutation is relatively random not specific

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9
Q

The commonly used animal model known as the beige mouse (lacking functional NK cells) was originally induced by which of these methods:

a. Chemical mutagenesis
b. Irradiation
c. genetic manipulation
d. single base pair spontaneous mutation
A

b

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10
Q

Floxed genes or mice are created by flanking a gene of interest with a loxP sequence in the genome. LoxP is the target of which enzyme that will allow excision of the sequence of interest and therefore ablation of the gene function

a. E.coli promoter1
b. Cas proteinase
c. Cre recombinase
d. TLR-4
A

c

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11
Q 
Give the full name of the following:
	ZFN		Z\_\_\_\_\_  F\_\_\_\_\_ N\_\_\_\_\_\_
	TALEN	T\_\_\_\_\_ A\_\_\_\_\_\_L\_\_\_\_\_E\_\_\_\_\_N\_\_\_\_\_\_
	YAC		Y\_\_\_\_\_\_A\_\_\_\_\_\_\_C\_\_\_\_\_\_\_\_
	CRISPR	C\_\_\_\_\_\_R\_\_\_\_\_\_I\_\_\_\_\_\_S\_\_\_\_\_\_P\_\_\_\_\_\_\_R\_\_\_\_\_
A

ZFN Zinc-finger nuclease
TALEN Transcription activator-like effector nuclease
YAC Yeast artificial chromosomes
CRISPR Clustered regularly interspaced short palindromic repeat

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12
Q

Which of the following scientist discovered Mycobacterium tuberculosis and developed tuberculin testing as a method to identify infected animals and people:

a. John Lister
b. Louis Pasteur
c. Robert Kock
d. Edward Jenner
A

c

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13
Q

The nude mouse was first described by Flanagan in 1966. This mouse has a spontaneous mutation of the developing thymus that results in lack of functional:

a. T cells
b. B cells
c. Macrophages
d. Antibody response
A

a

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14
Q

The SCID mouse has a mutation in which gene that renders it lacking in both T cell and B cell functionality:

a. TLR-1
b. rag 1
c. rag 2
d. Both c and d
A

b

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15
Q

The majority of influenza vaccines induce immunity to the two major surface glycoproteins known as:

a. Hemagglutinin and neuraminidase
b. Glycoprotein 1 and 2
c. env and pol
d. Hematin and nuclease
A

a

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16
Q

Which two strains of human papillomavirus cause the majority of cervical cancers and is the most common sexually transmitted disease in the US

a. HPV 6 and 11
b. HPV 12 and 14
c. HPV 13 and 15
d. HPV 16 and 18
A

d

17
Q

Fill in the blanks:
PRRs (Pattern Recognition Receptors) are a group of proteins that are capable of recognizing certain molecular or cellular patterns, PAMPs
(P_____ A______M_______P______s), which are indicative of pathogens.

A

Pathogen associated molecular patterns

18
Q

Toll-like Receptors, the most familiar of the PRRs, were characterized using spontaneously arising mouse models, specifically substrains of C3H/Hej and C57BL/10 which were resistant to the effects of administration of:

a. Streptozotocin
b. LPS
c. ENU
d. Tetanus toxoid
A

b

19
Q

Toll-like Receptors, the most familiar of the PRRs, were characterized using spontaneously arising mouse models, specifically substrains of C3H/Hej and C57BL/10 which were resistant to the effects of administration of:

a. Streptozotocin
b. LPS
c. ENU
d. Tetanus toxoid
A

b

20
Q

Genes which evolved from a common ancestral gene by speciation that retain a similar function are called:

	a. paralogs
	b. homologs
	c. orthologs
	d. semilogs
A

c

21
Q

SNP (single nucleotide polymorphism) are changes in a single nucleotide in a DNA sequence. T or F

A

T

22
Q

Two common and well-characterized epigenetic mechanisms influencing gene expression include methylation of histones and DNA molecules. T or F

A

t

23
Q

siRNS (small interfering RNA) is made up of single or double stranded RNA?

A

double

24
Q

The Indian-origin rhesus is thought the be the best model for HIV vaccine testing due to the similarity of the orthologous genes (to human) specifically encoding proteins regulating immunity which include:

	a. HLA proteins
	b. MHC proteins
	c. TLR molecules
	d. PAMPs
A

a

25
Q

A mouse model of Autism Spectrum disorder (ASD) used to focus on the microbiota and leakiness of the gut, found that transplanting this bacteria, corrected gut leakiness and behavioral symptoms associated with ASD:

	a. Clostridium difficle 
	b. Lactobacillis johnsonii
	c. Bacteroides fragillus
	d. Helicobacter hepaticus
A

c

26
Q

What is the traditional rat model used for toxicology studies?

A

F344

27
Q

What human disease does the BB Wistar Rat model?

Is this a spontaneous or induced model?

A

type 1 diabetes

spontaneous

28
Q

Is the Watanabe rabbit model an induced or spontaneous model?
What does it model

A

spontaneous

hypercholesterolemia

29
Q

What strain of rat models neurogenic diabetes?

Is it induced or spontaneous?

A

Brattleboro

spontaneous

30
Q

What is the benefit of using Danio rerio for developmental studies?

A

their embryos are transparent

ACLAM (32 decks)

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