Comp Med Dec 2016 Random questions

Question 1

What type of herpes virus is Epstein Barr?

Answer 1

gamma herpes

murine model of EBV- Murine Gamma Herpes virus (MuGHV)

Question 2

What is the model of cecal ligation and perforation in the mouse used to study?

Answer 2

“gold standard” model for sepsis

Question 3

What are the common clinical signs of wasting marmoset syndrome

Answer 3

weight loss, cachexia, chronic diarrhea, anemia, hypoalbuminemia, alopecia

• two main disease states- IBD and chronic enteritis
• contributes to 50-80% of marmoset deaths in captivity

Question 4

What is MMP9?

Answer 4

A member of the family of metalloproteinases, plays and important role in controlling inflammation by controlling some inflammatory cytokines. Reported to be elevated in human and mice IBD and in marmosets with MWS. It is activated by plasmin

Question 5

What is Tranexamic acid

Answer 5

Plasmin inhibitor,

• potential use in treating IBD in human is being investigated
• recent paper used it for Marmoset wasting syndromeWS

Question 6

T or F

A body weigh of less than 325g indicate wasting marmoset syndrome with a 96% positive predictive value

Answer 6

T

Question 7

A recent study showed significant improvement in MWS when treated with tranexamic acid

Answer 7

T
Improvements in multiple clinical parameters were noted. Alopecia as shown in image in article, anemia, hypoalbuminemia and BW (other supportive tx were used in conjunction with tranexamic acid)

Question 8

What helminth is responsible for a recent case of neurtocysticercosis in a rhesus monkey

Answer 8

Cysticercus cellulosae, which is the larva form of Taenia sodium the tapeworm of pigs (human is direct or indirect host)