Comp Med August 2016 Random questions

Question 1

What is an interesting and unexpected feature of the transgenic mouse made to overexpress ErbB2, that makes it a useful model for hypertrophic cardiomyopathy

Answer 1

Left ventricular hypertrophy and papillary muscle hypertophy

Question 2

Give the genus and species of the prostigmatid mite recently identified as causing infestation in 2 strains genetically modified immunomodulated mice

Answer 2

Demodex muscles

• cigar shaped, short stubby legs
• crusting skin and alopecia, excoriation
• transmitted from dam to pup during weaning
• tx- 2x/week amitraz bath (though did not seem effective in these cases), ivermectin/moxidectin, 2ndary antibiotics

Question 3

In what mouse strain has mucinous metaplasia of the prostate gland been recently identified at an increased incidence rate compared to previously reported

Answer 3

FVB/N

Question 4

What stain is usually used to identify mucinous glands

Answer 4

PAS

periodic acid-Schiff

Question 5

How many MHC haplotypes are there in Mauritian isolated population of cynomolgus monkeys?

Answer 5

6

-have limited genetic diversity due to isolation on the island of Mauritiius

Question 6

Is cobalamin (Vit B12) a fat soluble or water soluble vitamin?

Answer 6

water soluble

-not synthesized by the body, must be obtained in the diet

Question 7

What is the most commonly used medical treatment for endometriosis in NHPs

Answer 7

Depot medroxyprogesterone acetate

Question 8

Depot medroxyprogesterone acetate is known to increase or decrease insulin sensitivity?

Answer 8

Decrease. It contributes to insulin resistance