JAALAS Jan 2016 Random

Question 1

Genus species of African spiny mouse

Answer 1

Acomys cahirinus

Question 2

Acomys are an emerging animal model for what diseases

Answer 2

diet induced type-2 diabetes
regenerative medicine
diel rhythmicity
late-gestational development

Question 3

What is the gestation period of spiny mice?

Answer 3

38-45d
precocial newborns- haired, open eyes, unfolded ears, almost complete organogenesis and neurogenesis, will eat dry food on day 2 of life

Question 4

Tor F

Acomys have very weak skin, that easily tears in response to handling or attack

Answer 4

T

Question 5

T or F

Acomys are unique among rodents in that they do not have preputial glands

Answer 5

T

they do have accessary sex glands (prostate- large lateral,SV, coagulating and ampullary)

Question 6

T or F

15-30% of spiny mice may become diabetic on mouse chow and fatty seed diet

Answer 6

T
They are also prone to obesity. So careful attention to diet is essential (low protein mouse pellets w/limited sunflower seeds in 3:1 ratio is good)

Question 7

What is the required floor space for a female rat and her litter (according to 2011 guide)

Answer 7

124 sq in
(The addition of another adult, such as with a monogamous breeding pair, requires additional space based on the size of the additional animal)

Question 8

A recent study comparing IVC ammonia levels in rat cages using alpha cellulose vs corncob bedding determined which product to maintain lower ammonia levels out to 14 days?

Answer 8

corn cob

Question 9

What is the causative agent of hyperkarytotic dermatitis in Foxn1 nu/nu mice

Answer 9

Corynebacteria bovis

-causes short duration clinical signs, but may have lasting effects on the skin and on xenograft tumor development

Question 10

What is the treatment plan for irradiation of Corynebacteria bovis from nude mouse colonies?

Answer 10

depopulate, decontaminate, repopulate

-still only variably effective

Question 11

What is the HEM component of an IVC rack system

Answer 11

Horizontal exhaust manifold

Question 12

A recent study determined that quantitive PCR of swabs taken at the HEM was useful for early detection of C. bovis

Answer 12

T

Question 13

Is buprenorphine considered a partial mu agonist or antagonist?

Answer 13

agonist

Question 14

TorF

A recent study determined Bup-SR to be superior to Bup HCL in a laporatomy model in female mice

Answer 14

T

Question 15

What is the mechanism of action of tramodol?

Answer 15

mu opioid receptor agonist

also has serotonin and norepinephrine re-uptake inhibitors, and other activity too

Question 16

What receptor is sensitized by capsaicin?

Answer 16

vanilloid 1 (key channel for signaling and modulating heat and inflammatory pain)
Orofacial pain assessment device (OPAD)- capsaicin is applied to sensitize the skin prior adding heat to the area for assessment of pain response

Question 17

T or F
Propofol is a suitable anesthetic agent in rats, but is not that useful for urodynamic studies due to its marked suppression of bladder contractions and external urethral sphincter EMG.

Answer 17

T
Urethane is often the preferred anesthetic for these types of procedures due to it’s limited suppression of urodynamic parameters