Mouse and Rat nomenclature Flashcards
Name the genus and species of rat that is the primary contributed to laboratory rats
Rattus norvegicus
Who assigns the laboratory codes for rat and mouse nomenclature?
ILAR
When can strains be determined inbred?
After 20 consecutive brother sister matings. This will leave them only 0.01 residual heterozygosity
How should the naming of inbred strains begin?
upper case, Roman, letters
How are substrains designated
symbol of the orginal strain, foward slash (/) followed by substrain designation (which is usually the laboratory strain)
How are substrains defined?
If two branches are separated after 20 but before 40 generations of inbreeding
If branches are separated for mre than 20 generations from a common ancestor
If genetic difference is determined by genetic analysis
Mice or rats that are progeny of two inbred stains are called hybrids. There nomenclature will designate the maternal and paternal strains. Which is listed first?
maternal strain
What letters in the acceptiable mice and rat nomenclature system indicate it is a hybrid strain
F1
How are coisogenic strains defined
inbred strains that differ at only a single locus
How are coisogenic strains designated
strain and substrain given, followed by hyphen, then designation of the gene of the differential allele
How are congenic strains defined?
produced by repeated backcrosses (minimum of 10) to an inbred strain, with selection for a particular marker from the donor strain
What part of the nomenclature indicates it is a congenic strain?
A period betwen the recipient and donor strain
How are outbred stocks defined?
No two individuals are the same. Intentionally not bred to siblings or close relatives. Maintain maximum heterozygosity
How are outbred strains designated
Colon.
Laboratory code : common strain root abbreviation
