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Pharm Final > RA > Flashcards

RA Flashcards

1
Q

Rheumatoid Arthritis

a. long-term use of NSAIDs is an effective cure for rheumatoid arthritis

A

a) False, there is no cure RA. NSAIDs are used for short term pain management

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2
Q

Rheumatoid Arthritis

b. methotrexate toxicity is increased with folic acid supplementation

A

b) False, methotrexate is a folic acid antagonist. Therefore, folic acid supplementation will decrease methotrexate toxicity

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3
Q

Rheumatoid Arthritis

c. sulfasalazine is metabolised by gut bacteria into its active form

A

c) True, Cleaved in GIT sulfapyridine (RA) + 5-aminosalicylic acid (IBD)

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4
Q

Rheumatoid Arthritis

d. etanercept binds to TNF and inhibits it

A

d) True, binds circulating and receptor bound TNF alpha

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5
Q

Rheumatoid Arthritis

e. cyclosporine causes dose-related nephrotoxicity

A

e) True, cyclosporine is nephrotoxic

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6
Q

Drugs used in the management of rheumatoid arthritis

a. azathroprine is a folic acid antagonist

A

a. False. Azathioprine’s mechanism of action is not entirely understood but it may be related to inhibition of purine synthesis, along with inhibition of B and T cells. Methotrexate is a folic acid antagonist

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7
Q

Drugs used in the management of rheumatoid arthritis

b. methothrexate slows the progression of RA

A

b. True

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8
Q

Drugs used in the management of rheumatoid arthritis

c. cyclosporine is a nephrotoxic agent

A

c. True

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9
Q

Drugs used in the management of rheumatoid arthritis

d. sulfasalazine is used in the treatment of Crohn’s Disease

A

d. True, for Crohns and RA

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10
Q

Drugs used in the management of rheumatoid arthritis

e. chloroquine is converted to 5-ASA in the GIT

A

e. False, sulfasalazine is cleaved into 5-ASA

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11
Q

Rheumatoid Arthritis and Gout

a. celecoxib is used to manage pain in arthritis

A

a. True,

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12
Q

Rheumatoid Arthritis and Gout

b. sulfasalazine increases uric acid secretion in gout

A

b. False, sulfasalazine Inhibits T cell response and Decrease B cell antibody production in RA

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13
Q

Rheumatoid Arthritis and Gout

c. methotrexate inhibits DNA synthesis in immune cells

A

c. False, this is the MOA of leflunomide

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14
Q

Rheumatoid Arthritis and Gout

d. probenecid prevents the destruction of joints in rheumatoid arthritis

A

d. False, probenecid inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate in gout

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15
Q

Rheumatoid Arthritis and Gout

e. allopurinol inhibits xanthine oxidase

A

e. True, allopurinol is a xanthine oxidase enzyme inhibitor

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16
Q

In the treatment of rheumatoid arthritis and gout

a. methotrexate inhibits the action of tumour necrosis factor

A

a. False, folic acid antagonist that inhibits dihydrofolate reductase

17
Q

In the treatment of rheumatoid arthritis and gout

b. leflunomide is contraindicated prior to falling pregnant

A

b. True, requires a 2 year wash out period

18
Q

In the treatment of rheumatoid arthritis and gout

c. infliximab decreases circulating tumour necrosis factor

A

c. True, bind circulating and bound TNFa

19
Q

In the treatment of rheumatoid arthritis and gout

d. colchicine is used to treat rheumatoid arthritis

A

d. False, colchicine is used to treat acute gouty attacks

20
Q

In the treatment of rheumatoid arthritis and gout

e. aspirin is used as an analgesic in gout

A

e. False, may exacerbate gouty attacks

21
Q

In the treatment of rheumatoid arthritis

a. methotrexate inhibits DNA synthesis in immune cells

22
Q

In the treatment of rheumatoid arthritis

b. leflunomide is safe to use during pregnancy

A

b. False, requires a 2 year wash out period

23
Q

In the treatment of rheumatoid arthritis

c. infliximab binds to TNF-α

24
Q

In the treatment of rheumatoid arthritis

d. folic acid supplementation aggravates methotrexate-induced hepatotoxicity

A

d. False, methotrexate is a folic acid antagonist. Supplementation will reduce adverse effects

25
Q

In the treatment of rheumatoid arthritis

e. sulfasalazine is hepatotoxic

A

e. True, hepatotoxic, myelotoxic

26
Q

Disease modifying agents in rheumatoid arthritis

a. methotrexate causes mucosal ulceration

A

a. True. Methotrexate causes hepatotoxicity, mucosal ulceration and ulcers in the mouth and nephrotoxicity

27
Q

Disease modifying agents in rheumatoid arthritis

b. leflunomide inhibits T-cell proliferation

A

b. True, Inhibits mononuclear and Tcell proliferation

28
Q

Disease modifying agents in rheumatoid arthritis

c. sulfasalazine increases TNF-α levels in arthritic joints

A

c. False, reduces

29
Q

Disease modifying agents in rheumatoid arthritis

d. infliximab is safe to use in patients with latent tuberculosis

A

d. False, may activate the latent TB because of the immune suppression

30
Q

Disease modifying agents in rheumatoid arthritis

e. hydroxychloroquine is a folic acid antagonist

A

e. False, methotrexate is a folic acid antagonist. Hydroxychloroquine is a fluoroquinolone

Pharm Final (25 decks)

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