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Pharm Final > LA > Flashcards

LA Flashcards

1
Q

Local anaesthetic agents

a. lignocaine blocks the sensation of pain before motor function

A

a) True, type C fibres are blocked before motor functions

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2
Q

Local anaesthetic agents

b. ropivacaine inhibits A-fibres before C-fibres

A

b) False, type C fibres are blocked before motor functions

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3
Q

Local anaesthetic agents

c. tetracaine is an ester local anaesthetic

A

c) True

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4
Q

Local anaesthetic agents

d. the unionised form of lignocaine diffuses into the axon membrane

A

d) True, unionized LA diffuses to the target where it is ionized

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5
Q

Local anaesthetic agents

e. lignocaine is metabolised to para-aminobenzoic acid

A

e) False, esters are metabolized by plasma cholinesterases into para-aminobenzoic acid. Lignocaine is an amide

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6
Q

Local anaesthetic agents

a. lignocaine blocks the sensation of pressure before pain

A

A. False, the sensation of pain is blocked first

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7
Q

Local anaesthetic agents

b. ropivacaine inhibits C-fibres before A-fibres

A

B. True, c-fibres are inhibited first

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8
Q

Local anaesthetic agents

c. procaine is an ester local anaesthetic

A

C. True, procaine is a local anesthetic of the ester type that has a slow onset and a short duration of action.

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9
Q

Local anaesthetic agents

d. the ionised form of bupivacaine diffuses into the axon membrane

A

D. False, the unionized form of the LA diffuses into the axon membrane

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10
Q

Local anaesthetic agents

e. tetracaine is metabolised by pseudocholinesterase

A

E. True, esters are metabolized by plasma cholinestares

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11
Q

Local anaesthetic agents

a. the ionised form of lignocaine is more lipophilic than the non-ionised form

A

A. False, unionized lignocaine is more lipophilic

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12
Q

Local anaesthetic agents

b. bupivacaine has a shorter duration of action than procaine

A

B. False, bupivacaine has a longer DOA

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13
Q

Local anaesthetic agents

c. ropivacaine is less cardiotoxic than bupivacaine

A

C. True, bupivacaine causes ventricular fibrillation

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14
Q

Local anaesthetic agents

d. procaine is metabolised by plasma cholinesterase

A

D. True, esters are metabolized by plasma cholinesterases

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15
Q

Local anaesthetic agents

e. adrenaline decreases the duration of action of lignocaine

A

E. False, adrenaline localizes the action of lignocaine, thereby extending its DOA

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16
Q

Local anaesthetics

a. lignocaine is metabolised by plasma cholinesterase

A

a. False, amides are metabolized by the liver

17
Q

Local anaesthetics

b. bupivacaine is more cardiotoxic than lignocaine

A

b. True, causes ventricular fibrillation

18
Q

Local anaesthetics

c. procaine has a longer duration of action than lignocaine

A

c. False, procaine is very short acting

19
Q

Local anaesthetics

d. the non-ionised form of lignocaine inhibits passage of sodium through the neuronal cell

A

d. False, ionized lignocaine exhibits its effect

20
Q

Local anaesthetics

e. lignocaine crosses the blood brain barrier

A

e. True, crosses the BBB and the placenta

21
Q

Local anaesthetics

a. the unionized form of lignocaine crosses the neuronal membrane

A

a. True

22
Q

Local anaesthetics

b. procaine causes allergic dermatitis

A

b. True, procaine causes allergic dermatitis

23
Q

Local anaesthetics

c. bupivacaine is metabolised by plasma cholinesterase

A

c. False, bupivacaine is an amide and is thus metabolized by the liver

24
Q

Local anaesthetics

d. adrenaline shortens the duration of action of lignocaine

A

d. False, adrenaline prolongs the effects of lignocaine

25
Q

Local anaesthetics

e ropivacaine has a shorter half- life than procaine

A

e. False, procaine has a shorter half life than ropivacaine

26
Q

Lignocaine

a. undergoes hepatic metabolism

A

a. True, amides are metabolized in the liver

27
Q

Lignocaine

b. is more lipophilic than articaine

A

b. False, articaine has a thiophene ring which makes it more lipophilic

28
Q

Lignocaine

c. blocks the sensation of pain before motor function

A

c. True, blocks C fibres before A fibres

29
Q

Lignocaine

d. is more cardiotoxic than bupivicaine

A

d. False, bupivacaine is the most cardiotoxic

30
Q

Lignocaine

e. blocks C-fibres before A-fibres

A

e. True blocks C fibres before A fibres

31
Q

Local Anaesthetic – Bupivacaine

a. in the ionised form crosses the neuronal membrane

A

a. False, unionized

32
Q

Local Anaesthetic – Bupivacaine

b. is used for epidural infusion for postoperative pain control

A

b. True

33
Q

Local Anaesthetic – Bupivacaine

c. is more cardio toxic than lignocaine

A

c. True

34
Q

Local Anaesthetic – Bupivacaine

d. has a shorter duration of action than articaine

A

d. False

35
Q

Local Anaesthetic – Bupivacaine

e. reduced doses are indicated in hepatic disease

A

e. True, amides are metabolised by the liver

36
Q 
A 55 year-old male requires stitches after an injury. He requires a short-acting local anaesthetic. He has a plasma cholinesterase deficiency. Which agent from the list above
is commonly used for this purpose?
1.	Articaine
2.	Bupivacaine
3.	Levobupicaine 
4.	Lignocaine
5.	Procaine
6.	Ropivacaine
A

Lignocaine

Pharm Final (25 decks)

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