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Pharm Final > NSAIDS > Flashcards

NSAIDS Flashcards

1
Q

Non Steroidal Anti-inflammatory Drugs (NSAIDs)

a. NSAIDs inhibit lipocortin

A

a. False, NSAIDs inhibit cyclooxygenase

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2
Q

Non Steroidal Anti-inflammatory Drugs (NSAIDs)

b. ibuprofen is an effective anticoagulant

A

b. True, NSAIDs inhibit prostaglandins and therefore cause anticoagulation

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3
Q

Non Steroidal Anti-inflammatory Drugs (NSAIDs)

c. meloxicam selectively inhibits COX-II enzyme

A

c. True, meloxicam, diclofenac and celecoxib are COX-II selective

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4
Q

Non Steroidal Anti-inflammatory Drugs (NSAIDs)

d. indomethacin can precipitate bronchospasm in an asthmatic patient

A

d. True

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5
Q

Non Steroidal Anti-inflammatory Drugs (NSAIDs)

e. diclofenac is more likely than celecoxib to cause gastric ulceration

A

e. True the more COX-II selective the drug the less likely to result in gastric ulceration

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6
Q

Paracetamol

a. is an effective antipyretic in children with bacterial infections

A

a. True, paracetamol has analgesic and antipyretic effects and is safe for children

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7
Q

Paracetamol

b. is preferred to diclofenac when treating rheumatoid arthritis

A

b. False,

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8
Q

Paracetamol

c. is safe in overdose

A

c. False, overdose of paracetamol hepatic necrosis and renal tubular damage

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9
Q

Paracetamol

d. inhibits COX-III

A

d. True Studies also suggest that acetaminophen (paracetamol) selectively blocks a variant type of the COX enzyme that is unique from the known variants COX-1 and COX-2. This enzyme has been referred to as COX-3.

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10
Q

Paracetamol

e. is a safe anticoagulant in hypertensive patients

A

e. False, paracetamol is a poor anticoagulant and NSAIDs reduce effectiveness of anti-hypertensives

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11
Q

NSAID Agents

a. aspirin inhibits platelet aggregation

A

a. True, aspirin inhibits thromboxane A2 inhibiting platelet aggregation

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12
Q

NSAID Agents

b. ibuprofen is used to treat pyrexia in children

A

b. True, ibuprofen is an effective treatment for pyrexia and is safe in children

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13
Q

NSAID Agents

c. indomethacin is safer than celecoxib in patients with peptic ulcer disease (PUD)

A

c. False, COX-II selective NSAIDs have a 50% reduction in GIT adverse effects

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14
Q

NSAID Agents

d. celecoxib causes less GIT side effects than diclofenac

A

d. True, celecoxib is more COX-II selective than diclofenac

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15
Q

NSAID Agents

e. mefenamic acid is preferred to pethidine to treat visceral pain

A

e. True, visceral pain is treated using an agent specific to the cause. Mefenamic acid for dysmenorrhea, hyoscine for stomach cramps etc

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16
Q

Paracetamol and the NSAIDs

a. paracetamol stimulates COX-III centrally

A

a. False , Studies also suggest that acetaminophen selectively blocks a variant type of the COX enzyme that is unique from the known variants COX-1 and COX-2. This enzyme has been referred to as COX-3.

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17
Q

Paracetamol and the NSAIDs

b. celecoxib inhibits COX-I

A

b. False, celecoxib is COX-II selective

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18
Q

Paracetamol and the NSAIDs

c. use of naproxen increases the risk of GIT perforations

A

c. True, naproxen is a non-selective NSAID

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19
Q

Paracetamol and the NSAIDs

d. celecoxib is used in the management of rheumatoid arthritis

A

d. True

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20
Q

Paracetamol and the NSAIDs

e. paracetamol is more active against COX-II than diclofenac

A

e. False. Paracetamol is non-selective and diclofenac is more COX-II selective

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21
Q

NSAIDs

a. asprin inhibits COX II activity

A

a. True, aspirin is a non-selective COX inhibitor and thus, inhibits COX I and COX II

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22
Q

NSAIDs

b. ibuprofen increases the risk of bleeding

A

b. True, inhibits housekeeping enzymes thus, increases the risk of bleeding

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23
Q

NSAIDs

c. diclofenac is used to decrease pain during labour

A

c. False, diclofenac is CI. Use low dose pethidine

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24
Q

NSAIDs

d. in patients with ulcers, aspirin increases the risk of gastric bleeding

A

d. True, aspirin increases the risk of bleeding

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25
Q

NSAIDs

e. celecoxib selectively inhibits cyclooxygenase I activity

A

e. False, celecoxib selectively inhibits COX II

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26
Q

Pain and inflammation

a. inhaled fluticasone decreases pulmonary inflammation

A

a. True, IGCS reduced pulmonary inflammation

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27
Q

Pain and inflammation

b. codeine potentiates the anti-inflammatory effect of prednisone

A

b. False, codeine isn’t anti-inflammatory

28
Q

Pain and inflammation

c. prednisone inhibits the formation of prostaglandin G in inflamed tissue

A

c. True

29
Q

Pain and inflammation

d. betamethasone is used to treat steroid associated acne

A

d. True

30
Q

Pain and inflammation

e. methylprednisolone improves lung function in pre-term neonates

A

e. False, give dexamethasone

31
Q

Pain, inflammation and analgesia

a. paracetamol reduces the production of PGE2 in inflamed arthritic joints

A

a. False, poor peripheral activity

32
Q

Pain, inflammation and analgesia

b. diclofenac inhibits the action of phospholipase A2

A

b. False, diclofenac selectively inhibits cyclo-oxygenase II (COX-II)

33
Q

Pain, inflammation and analgesia

c. glucocorticosteroids inhibit the activity of lipooxygenase

A

c. True, steroids inhibit phospholipase A2. Phospholipase A2 converts arachidonic acid into cyclooxygenase/ lipooxygenase

34
Q

Pain, inflammation and analgesia

d. aspirin decreases the production of prostacyclin from the endothelium

A

d. True, aspirin inhibits prostacyclin

35
Q

Pain, inflammation and analgesia

e. naproxen inhibits the activity of gastric mucosal cyclooxygenase

A

e. True, naproxen is a COX inhibitor

36
Q

Anti-inflammatory drugs at therapeutic doses

a. naproxen inhibits platelet aggregation

A

a. True, NSAIDs inhibit house keeping prostaglandins and therefore inhibit platelet aggregation

37
Q

Anti-inflammatory drugs at therapeutic doses

b. ibuprofen binds reversibly to mucosal COX I

A

b. True. Non-selective cox inhibitors will bind

38
Q

Anti-inflammatory drugs at therapeutic doses

c. celecoxib inhibits the production of PGE2 in rheumatoid arthritis

A

c. False, PGE2 is a housekeeping enzyme responsible for gastric cytoprotection. COX 1 inhibition inhibits housekeeping house keeping enzymes. Celecoxib is COX -2 selective

39
Q

Anti-inflammatory drugs at therapeutic doses

d. diclofenac is less active than etoricoxib against gastric cyclooxygenase

A

d. False, etoricoxib is more selective for COX 2 than diclofenac. Therefore, diclofenac will be more active against gastric cyclooxygenase

40
Q

Anti-inflammatory drugs at therapeutic doses

e. ibuprofen decreases the risk of mucosal perforation in patients with rheumatoid arthritis

A

e. False, ibuprofen inhibits house keeping enzymes and thus will cause gastric irritation

41
Q

NSAID’s and paracetamol

a. ibuprofen is more active in inhibiting cyclooxygenase II than paracetamol

A

a. False, both are non-selective cox inhibitors

42
Q

NSAID’s and paracetamol

b. paracetamol increases the production of cerebral PGE2

A

b. False, paracetamol inhibits COX I and II in the brain

43
Q

NSAID’s and paracetamol

c. diclofenac reduces production of PGE2 in the kidney

A

c. True

44
Q

NSAID’s and paracetamol

d. etoricoxib is more selective for mucosal COX I than COX II

A

d. False, cox 2 inhibitor

45
Q

NSAID’s and paracetamol

e. paracetamol has less activity against renal cyclooxygenase I than diclofenac

A

e. True, paracetamol is a poor peripheral inhibitor of COX

46
Q

Paracetamol

a. Is safer than aspirin for use in patients with gastric ulcers

A

a. True

47
Q

Paracetamol

b. inhibits the activity of cyclooxygenase in the brain

A

b. True

48
Q

Paracetamol

c. has greater peripheral anti-inflammatory effects than ibuprofen

A

c. False

49
Q

Paracetamol

d. naloxone is used as an antidote in paracetamol toxicity

A

d. False, opioid receptor antagonist

50
Q

Paracetamol

e. reduces fever in children

A

e. True

51
Q

NSAIDS

a. paracetamol is preferred to diclofenac during pregnancy

A

a. True

52
Q

NSAIDS

b. diclofenac is more selective for COX II than for COX I

A

b. False

53
Q

NSAIDS

c. naproxen is more selective than celecoxib for COX I

A

c. True

54
Q

NSAIDS

d. aspirin stimulates the production of thromboxane A2 in platelets

A

d. False

55
Q

NSAIDS

e. diclofenac inhibits the formation of PGE2 in gastric mucosa

A

e. True (COX1 inhibition)

56
Q

Pain, inflammation and analgesia

a. paracetamol reduces the production of PGE2 in inflamed arthritic joints

A

a. False, poor peripheral COX inhibition

57
Q

Pain, inflammation and analgesia

b. diclofenac inhibits the action of phospholipase A2

A

b. False, diclofenac selectively inhibits cyclo-oxygenase II (COX-II)

58
Q

Pain, inflammation and analgesia

c. glucocorticosteroids inhibit the activity of lipooxygenase

A

c. True,

59
Q

Pain, inflammation and analgesia

d. aspirin decreases the production of prostacyclin from the endothelium

A

d. True, aspirin inhibits prostacyclin

60
Q

Pain, inflammation and analgesia

e. naproxen inhibits the activity of gastric mucosal cyclooxygenase

A

e. True, naproxen is a COX inhibitor

61
Q

NSAID’s and paracetamol

a. ibuprofen is more active in inhibiting cyclooxygenase II than paracetamol

A

a. False, both are non-selective cox inhibitors

62
Q

NSAID’s and paracetamol

b. paracetamol increases the production of cerebral PGE2

A

b. False, inhibits the production cerebral COX, thereby decreasing PGE2 production

63
Q

NSAID’s and paracetamol

c. diclofenac reduces production of PGE2 in the kidney

A

c. True

64
Q

NSAID’s and paracetamol

d. etoricoxib is more selective for mucosal COX I than COX II

A

d. False, cox 2 inhibitor

65
Q

NSAID’s and paracetamol

e. paracetamol has less activity against renal cyclooxygenase I than diclofenac

A

e. True, poor peripheral inhibtion

Pharm Final (25 decks)

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