Anti-fungals Flashcards by Josh Datnow

In the treatment of fungal infections

a. IV amphotericin B is nephrotoxic

A. True, amphotericin B is nephrotoxic and causes hypokalaemia and hypomagnaesemia

How well did you know this?

Not at all

Perfectly

In the treatment of fungal infections

b. IV fluconazole is contraindicated in systemic candidiasis

B. False, IV fluconazole is indicated for systemic candidiasis, vaginal and oral candidiasis and cryptococcal meningitis

How well did you know this?

Not at all

Perfectly

In the treatment of fungal infections

c. nystatin drops are contraindicated for use in babies

C. False, nystatin are safe for infant use

How well did you know this?

Not at all

Perfectly

In the treatment of fungal infections

d. terbinafine is used to treat athletes foot

D. True

How well did you know this?

Not at all

Perfectly

In the treatment of fungal infections

e. voriconazole is used to treat Aspergillus infections

E. True, voriconazole is use to treat aspergillus and candidiasis

How well did you know this?

Not at all

Perfectly

Azole antifungals

a. inhibit fungal lanosterol 14-demethylase

a. True, azole antifungals MOA: Inhibits fungal P450 enzymes, inhibits ergosterol synth (cell membrane) by inhibiting 14-demethylase

How well did you know this?

Not at all

Perfectly

Azole antifungals

b. cause congenital skeletal malformations when used in the first trimester of pregnancy

b. True

How well did you know this?

Not at all

Perfectly

Azole antifungals

c. fluconazole induces cytochrome P450 enzymes

c. False, azole antifungals inhibit cytochrome p450 enzymes

How well did you know this?

Not at all

Perfectly

Azole antifungals

d. itraconazole is hepatotoxic

d. True, only fluconazole isn’t as its metabolized by the kidneys

How well did you know this?

Not at all

Perfectly

Azole antifungals

e. fluconazole is effective against Aspergillus infections

e. False, aspergillus is treated with voriconazole or amphotericin B

How well did you know this?

Not at all

Perfectly

Topical antifungals

a. terbinafine increases fungal ergosterol synthesis

a. False, inhibits ergosterol synth (cell membrane) by inhibiting squalene epoxidase

How well did you know this?

Not at all

Perfectly

Topical antifungals

b. nystatin is used in the treatment of oral candidiasis in infants

b. True, safe in infants

How well did you know this?

Not at all

Perfectly

Topical antifungals

c. clotrimazole is used in the treatment of vulvovaginal candidiasis

c. True, clotrimazole is indicated in the treatment of dermatophytes, oral and vulvovaginal candidiasis

How well did you know this?

Not at all

Perfectly

Topical antifungals

d. terbinafine is used as first line therapy in the treatment of athletes foot

d. True

How well did you know this?

Not at all

Perfectly

Topical antifungals

e. terbinafine is ineffective against Tinea corporis

e. False, terbinafine can be used to treat tinea corporis, pedis and cruris

How well did you know this?

Not at all

Perfectly

Antifungal agents

a. iv amphotericin B is used to treat systemic candidiasis

a. True, amphotericin B is indicated for Systemic Candida, Cryptococcus, Aspergillus, Histoplasma, Blastomyces, Coccidioidis

How well did you know this?

Not at all

Perfectly

Antifungal agents

b. fluconazole is used to treat dermatophyte infections

b. False, used to treat Systemic candidiasis Vaginal & oropharyngeal candidiasis (not resp to topical tx Cryptococcal Meningitis

How well did you know this?

Not at all

Perfectly

Antifungal agents

c. nystatin drops are used to treat intestinal candidiasis in babies

c. True

Antifungal agents

d. clotrimazole is contraindicated for use in recurrent vaginal candidiasis

d. False, clotrimazole is indicated for use in recurrent vaginal candidiasis

Antifungal agents

e. terbinafine is used to treat cryptococcal meningitis

e. False, amphotericin b or fluconazole

Topical antifungals

a. terbinafine stimulates fungal squalene epoxidase activity

a. False, terbinafine is an allyl amine that MOA: inhibits ergosterol synth (cell membrane) by inhibiting squalene epoxidase

Topical antifungals

b. nystatin is absorbed through the GIT

b. False, Nystatin is not absorbed into the systemic circulation

Topical antifungals

c. clotrimazole is used in the treatment of Tinea corporis

c. True, clotrimazole is used in the treat of dermatophytes (Tinea), oral/vaginal candidiasis

Topical antifungals

d. clotrimazole is used in the treatment of cutaneous candidiasis

d. True, clotrimazole is used in the treat of dermatophytes (Tinea), oral/vaginal candidiasis

Topical antifungals | e. terbinafine is ineffective against Tinea pedis (athletes foot)

e. False, terbinafine is first line treatment for athletes foot

Antifungals | a. fluconazole inhibits cytochrome P450 enzymes

a. True, azole antifungals inhibit p450 enzymes

Antifungals | b. fluconazole inhibits fungal ergosterol synthesis

b. True, azole antifungals inhibits ergosterol synth (cell membrane) by inhibiting 14 demethylase

Antifungals | c. itraconazole is safe to use in patients with advanced liver failure

c. False, itraconazole is hepatotoxic

Antifungals | d. fluconazole is effective against aspergilosis

d. False, use amphotericin B or voriconazole

Antifungals | e. fluconazole is preferred to amphotericin B for invasive candidiasis in the first trimester of pregnancy

e. False, fluconazole is CI in pregnancy as it is teratogenic

Antifungal agents: | a. Itraconazole is used to treat candidiasis

a. True, itraconazole is indicated for candidiasis, dermatophytes, onychomycosis and dimorphic fungal infections

Antifungal agents: | b. IV amphotericin B is used to treat life threatening fungal infections

b. True

Antifungal agents: | c. Fluconazole inhibits fungal DNA synthesis

c. False, azole fungal infections MOA: Inhibits fungal P450 enzymes, inhibits ergosterol synth (cell membrane) by inhibiting 14 demethylase

Antifungal agents: | d. Clotrimazole is CI for use in mucocutaneous fungal infections

d. False, clotrimazole is indicated for the treatment of vaginal and oral candidiasis

Antifungal agents: | e. Nystatin is safe to use in babies

e. True

Antifungal agents: | a. IV amphotericin B is used to treat systemic candidiasis

a. True, amphotericin B is indicated for Systemic Candida, Cryptococcus, Aspergillus, Histoplasma, Blastomyces, Coccidioidis

Antifungal agents: | b. Fluconazole is used to treat dermatophyte infections

b. False, used to treat systemic/oral/ vaginal candidiasis and cryptococcal meningitis

Antifungal agents: | c. Nystatin drops are used to treat intestinal candidiasis in babies

c. True

Antifungal agents: | d. Clotrimazole is CI for use in recurrent vaginal candidiasis

d. False, indicated

Antifungal agents: | e. Terbinafine is used to treat cryptococcal meningitis

e. False, athletes foot. Treat cryptococcal meningitis with amphotericin B or fluconazole

In the treatment of candidiasis: | a. Nystatin drops are used to treat oral candidiasis in babies

a. True

In the treatment of candidiasis: | b. IV amphotericin B is nephrotoxic

b. True, poes toxic

In the treatment of candidiasis: | c. Fluconazole penetrates the BBB

c. True, indicated for cryptococcal meningitis

In the treatment of candidiasis: | d. Terbinafine is effective against aspergillus infections

d. False, aspergillus is treated with voriconazole or amphotericin B or capsofungin