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Pharm Final > Anti-fungals > Flashcards

Anti-fungals Flashcards

1
Q

In the treatment of fungal infections

a. IV amphotericin B is nephrotoxic

A

A. True, amphotericin B is nephrotoxic and causes hypokalaemia and hypomagnaesemia

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2
Q

In the treatment of fungal infections

b. IV fluconazole is contraindicated in systemic candidiasis

A

B. False, IV fluconazole is indicated for systemic candidiasis, vaginal and oral candidiasis and cryptococcal meningitis

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3
Q

In the treatment of fungal infections

c. nystatin drops are contraindicated for use in babies

A

C. False, nystatin are safe for infant use

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4
Q

In the treatment of fungal infections

d. terbinafine is used to treat athletes foot

A

D. True

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5
Q

In the treatment of fungal infections

e. voriconazole is used to treat Aspergillus infections

A

E. True, voriconazole is use to treat aspergillus and candidiasis

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6
Q

Azole antifungals

a. inhibit fungal lanosterol 14-demethylase

A

a. True, azole antifungals MOA: Inhibits fungal P450 enzymes, inhibits ergosterol synth (cell membrane) by inhibiting 14-demethylase

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7
Q

Azole antifungals

b. cause congenital skeletal malformations when used in the first trimester of pregnancy

A

b. True

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8
Q

Azole antifungals

c. fluconazole induces cytochrome P450 enzymes

A

c. False, azole antifungals inhibit cytochrome p450 enzymes

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9
Q

Azole antifungals

d. itraconazole is hepatotoxic

A

d. True, only fluconazole isn’t as its metabolized by the kidneys

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10
Q

Azole antifungals

e. fluconazole is effective against Aspergillus infections

A

e. False, aspergillus is treated with voriconazole or amphotericin B

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11
Q

Topical antifungals

a. terbinafine increases fungal ergosterol synthesis

A

a. False, inhibits ergosterol synth (cell membrane) by inhibiting squalene epoxidase

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12
Q

Topical antifungals

b. nystatin is used in the treatment of oral candidiasis in infants

A

b. True, safe in infants

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13
Q

Topical antifungals

c. clotrimazole is used in the treatment of vulvovaginal candidiasis

A

c. True, clotrimazole is indicated in the treatment of dermatophytes, oral and vulvovaginal candidiasis

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14
Q

Topical antifungals

d. terbinafine is used as first line therapy in the treatment of athletes foot

A

d. True

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15
Q

Topical antifungals

e. terbinafine is ineffective against Tinea corporis

A

e. False, terbinafine can be used to treat tinea corporis, pedis and cruris

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16
Q

Antifungal agents

a. iv amphotericin B is used to treat systemic candidiasis

A

a. True, amphotericin B is indicated for Systemic Candida, Cryptococcus, Aspergillus, Histoplasma, Blastomyces, Coccidioidis

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17
Q

Antifungal agents

b. fluconazole is used to treat dermatophyte infections

A

b. False, used to treat Systemic candidiasis Vaginal & oropharyngeal candidiasis (not resp to topical tx Cryptococcal Meningitis

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18
Q

Antifungal agents

c. nystatin drops are used to treat intestinal candidiasis in babies

A

c. True

19
Q

Antifungal agents

d. clotrimazole is contraindicated for use in recurrent vaginal candidiasis

A

d. False, clotrimazole is indicated for use in recurrent vaginal candidiasis

20
Q

Antifungal agents

e. terbinafine is used to treat cryptococcal meningitis

A

e. False, amphotericin b or fluconazole

21
Q

Topical antifungals

a. terbinafine stimulates fungal squalene epoxidase activity

A

a. False, terbinafine is an allyl amine that MOA: inhibits ergosterol synth (cell membrane) by inhibiting squalene epoxidase

22
Q

Topical antifungals

b. nystatin is absorbed through the GIT

A

b. False, Nystatin is not absorbed into the systemic circulation

23
Q

Topical antifungals

c. clotrimazole is used in the treatment of Tinea corporis

A

c. True, clotrimazole is used in the treat of dermatophytes (Tinea), oral/vaginal candidiasis

24
Q

Topical antifungals

d. clotrimazole is used in the treatment of cutaneous candidiasis

A

d. True, clotrimazole is used in the treat of dermatophytes (Tinea), oral/vaginal candidiasis

25
Q

Topical antifungals

e. terbinafine is ineffective against Tinea pedis (athletes foot)

A

e. False, terbinafine is first line treatment for athletes foot

26
Q

Antifungals

a. fluconazole inhibits cytochrome P450 enzymes

A

a. True, azole antifungals inhibit p450 enzymes

27
Q

Antifungals

b. fluconazole inhibits fungal ergosterol synthesis

A

b. True, azole antifungals inhibits ergosterol synth (cell membrane) by inhibiting 14 demethylase

28
Q

Antifungals

c. itraconazole is safe to use in patients with advanced liver failure

A

c. False, itraconazole is hepatotoxic

29
Q

Antifungals

d. fluconazole is effective against aspergilosis

A

d. False, use amphotericin B or voriconazole

30
Q

Antifungals

e. fluconazole is preferred to amphotericin B for invasive candidiasis in the first trimester of pregnancy

A

e. False, fluconazole is CI in pregnancy as it is teratogenic

31
Q

Antifungal agents:

a. Itraconazole is used to treat candidiasis

A

a. True, itraconazole is indicated for candidiasis, dermatophytes, onychomycosis and dimorphic fungal infections

32
Q

Antifungal agents:

b. IV amphotericin B is used to treat life threatening fungal infections

A

b. True

33
Q

Antifungal agents:

c. Fluconazole inhibits fungal DNA synthesis

A

c. False, azole fungal infections MOA: Inhibits fungal P450 enzymes, inhibits ergosterol synth (cell membrane) by inhibiting 14 demethylase

34
Q

Antifungal agents:

d. Clotrimazole is CI for use in mucocutaneous fungal infections

A

d. False, clotrimazole is indicated for the treatment of vaginal and oral candidiasis

35
Q

Antifungal agents:

e. Nystatin is safe to use in babies

A

e. True

36
Q

Antifungal agents:

a. IV amphotericin B is used to treat systemic candidiasis

A

a. True, amphotericin B is indicated for Systemic Candida, Cryptococcus, Aspergillus, Histoplasma, Blastomyces, Coccidioidis

37
Q

Antifungal agents:

b. Fluconazole is used to treat dermatophyte infections

A

b. False, used to treat systemic/oral/ vaginal candidiasis and cryptococcal meningitis

38
Q

Antifungal agents:

c. Nystatin drops are used to treat intestinal candidiasis in babies

A

c. True

39
Q

Antifungal agents:

d. Clotrimazole is CI for use in recurrent vaginal candidiasis

A

d. False, indicated

40
Q

Antifungal agents:

e. Terbinafine is used to treat cryptococcal meningitis

A

e. False, athletes foot. Treat cryptococcal meningitis with amphotericin B or fluconazole

41
Q

In the treatment of candidiasis:

a. Nystatin drops are used to treat oral candidiasis in babies

A

a. True

42
Q

In the treatment of candidiasis:

b. IV amphotericin B is nephrotoxic

A

b. True, poes toxic

43
Q

In the treatment of candidiasis:

c. Fluconazole penetrates the BBB

A

c. True, indicated for cryptococcal meningitis

44
Q

In the treatment of candidiasis:

d. Terbinafine is effective against aspergillus infections

A

d. False, aspergillus is treated with voriconazole or amphotericin B or capsofungin

Pharm Final (25 decks)

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