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Pharm Final > Antivirals > Flashcards

Antivirals Flashcards

1
Q

The antiviral agent is correctly paired with its use

a. oseltamivir – influenza

A

a. True, for influenza A and B

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2
Q

The antiviral agent is correctly paired with its use

b. acyclovir – Herpes simplex infections

A

b. True, treatment of HSV (I & II), varicella zoster virus, prophylaxis of recurrent episodes (>6/year) of herpes genitalis

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3
Q

The antiviral agent is correctly paired with its use

c. enfuvirtide – prevention of mother to child transmission in HIV

A

c. False, ENF is a fusion inhibitor. Give TDF + FTC + EFV (2 x NRTI and NNRTI)

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4
Q

The antiviral agent is correctly paired with its use

d. lopinavir – resistant Herpes simplex infections

A

d. False, PI for HIV

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5
Q

The antiviral agent is correctly paired with its use

e. lamivudine – HIV prophylaxis

A

e. True, PrEP is either tenofovir/ entricitabine or tenofovir/ lamivudine

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6
Q

Acyclovir

a. is an acyclic adenosine analogue

A

a. False, guanosine analogue

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7
Q

Acyclovir

b. is more active against CMV than HSV

A

b. False, primarily indicated for HSVS

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8
Q

Acyclovir

c. inhibits viral DNA synthesis

A

c. True, DNA polymerase inhibitor

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9
Q

Acyclovir

d. causes crystal nephropathy

A

d. True

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10
Q

Acyclovir

e. is used in the last trimester of pregnancy to prevent congenital herpes

A

e. True, acyclovir treatment beginning at 36 weeks’ gestation for women who have recurrent genital HSV infection in pregnancy reduces the incidence of caesarean deliveries and viral transmission.

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11
Q

Antiviral agents: acyclovir

a. has activity against HIV

A

a. False. Indicated for treatment of HSV (I & II), varicella zoster virus, prophylaxis of recurrent episodes (>6/year) of herpes genitalis

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12
Q

Antiviral agents: acyclovir

b. is effective against influenza infections

A

b. False.

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13
Q

Antiviral agents: acyclovir

c. is an acyclic guanosine analogue

A

c. True

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14
Q

Antiviral agents: acyclovir

d. causes crystal nephropathy as an adverse effect

A

d. True

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15
Q

Antiviral agents: acyclovir

e. crosses the blood brain barrier

A

e. True, Acyclovir crosses the blood-brain barrier, a desirable quality for the treatment of herpes encephalitis, neonatal herpes simplex virus infections, and, possibly, multiple sclerosis

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16
Q

Antiviral agents: oseltamivir

a. inhibits nucleic acid synthesis in the influenza virus

A

a. False. Inhibits neuraminidase enzyme, preventing the spread of virus

17
Q

Antiviral agents: oseltamivir

b. decreases the total duration of symptoms of influenza A infections

A

b. True

18
Q

Antiviral agents: oseltamivir

c. is effective against influenza B virus infections

A

c. True, A and B

19
Q

Antiviral agents: oseltamivir

d. has activity against hepatitis B

A

d. False.

20
Q

Antiviral agents: oseltamivir

e. is used in the treatment of CMV infections

A

e. False, is used to treat influenza A and B

21
Q

The clinical uses of acyclovir are as follows:

a. HIV post-exposure prophylaxis

A

False

22
Q

The clinical uses of acyclovir are as follows:

b. Herpes simplex infections

A

True

23
Q

The clinical uses of acyclovir are as follows:

c. acute Varicella zoster infections in adults

A

True

24
Q

The clinical uses of acyclovir are as follows:

d. hepatitis B virus infections

A

False

25
Q

The clinical uses of acyclovir are as follows:

e. influenza infections

A

False

26
Q

Non-retroviral agents

a. aciclovir inhibits DNA synthesis

A

A. True, dna polymerase inhibitor

27
Q

Non-retroviral agents

b. oseltamivir inhibits viral neuramidase

A

B. True

28
Q

Non-retroviral agents

c. In HIV positive patients, acyclovir is used as prophylaxis against cytomegalovirus (CMV) infections

A

C. False, acyclovir is used for HSV

Pharm Final (25 decks)

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