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Pharm Final > Glucorticosteroids questions > Flashcards

Glucorticosteroids questions Flashcards

1
Q

Effects of oral glucocorticosteroid use (>1 month)

a. decreased blood glucose levels

A

a. False. Increased

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2
Q

Effects of oral glucocorticosteroid use (>1 month)

b.osteoporosis

A

b. True.

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3
Q

Effects of oral glucocorticosteroid use (>1 month)

c.anabolic effect on muscle

A

c. False. Catabolic

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4
Q

Effects of oral glucocorticosteroid use (>1 month)

d. increased susceptibility to infection

A

d. True. Suppresses the immune response

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5
Q

Effects of oral glucocorticosteroid use (>1 month)

e. oedema in the elderly

A

e. True. Cause sodium retention. Therefore, cause oedema

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6
Q

Glucocorticosteroids

a. excessive use causes the suppression of the hypothalamic-pituitary-adrenal axis

A

a. True

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7
Q

Glucocorticosteroids

b oral glucocorticosteroids are contraindicated in the management of auto-immune disease

A

b. False. They are used to treat

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8
Q

Glucocorticosteroids

c.stimulate lung maturation in premature neonates

A

c. True

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9
Q

Glucocorticosteroids

d. prevents the formation of NSAID-associated gastric ulceration

A

d. False. Increase the likelihood

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10
Q

Glucocorticosteroids

e. topically applied hydrocortisone does not cause thinning of the skin

A

e. False. All cause skin thinning

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11
Q

The effects of glucocorticosteroids include

a. anti-inflammatory

A

a. True

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12
Q

The effects of glucocorticosteroids include

b. stimulates the T-cell response

A

b. False. inhibit the immune response

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13
Q

The effects of glucocorticosteroids include

c. increases the response to vaccines

A

c. False. inhibits the immune response

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14
Q

The effects of glucocorticosteroids included. decreases prostaglandin synthesis

A

d. True

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15
Q

The effects of glucocorticosteroids include

e. stimulates wound healing

A

e. False

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16
Q

In the therapeutic use of glucocorticosteroids

a. oral prednisolone increases blood glucose levels

A

a. True

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17
Q

b. glucocorticosteroid receptors are located in the cell membrane

A

b. False. BINDS Cytoplasmic glucocorticoid receptor

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18
Q

c. repeated cortisone injections increase the risk of osteonecrosis

A

c. True

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19
Q

d. in the elderly, oral glucocoticosteroid use increases fluid retention

A

d. True. increases sodium retention. Therefore, increases fluid retention

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20
Q

e. the use of oral methylprednisolone for more than two weeks increases circulating levels of ACTH

A

e. False

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21
Q

Corticosteroids

a. prednisone inhibits COX-I and COX-II

A

a. True. Steroids inhbit the genes encoding lipocortin. Therefore, decrease synthesis. Lipocortin stimulates phospholipase A2. PA2 stimulates cyclooxygenase producing COX 1 and 2

22
Q

b. phospholipase A2 is stimulated by lipocortin

A

b. True.

23
Q

c. beclomethasone is given to asthmatic patients to reduce inflammation

A

c. True

24
Q

d. cortisone will precipitate allergic reactions

A

d. False. given for allergic reactions

25
Q

e. corticosteroids modify enzyme activity

A

e. True.

26
Q

Adverse-effects of corticosteroids

a. corticosteroids have an anabolic effect on muscles and are used as muscle bulkers

A

a. False. Catabolic

27
Q

b. long-term treatment with prednisone causes dysregulation of the HPA-axis

A

b. True. Should be weened off

28
Q

c. hydrocortisone stimulates bone growth in children

A

c. False. Bone catabolism

29
Q

d. glucose levels are elevated with corticosteroid treatment

A

d. True

30
Q

e. a “moon face” and “buffalo hump” are characteristic of long-term prednisone treatment

A

e. True.

31
Q

Glucocorticosteroids

a. prednisolone suppresses allergic reactions

A

a. True

32
Q

b. oral betamethasone increases circulating levels of ACTH

A

b. False. Low cortisol stimulates ACTH production. Thus, induction of a GCS will decrease ACTH production

33
Q

c. hydrocortisone is used to treat ddison’s disease

A

c. True

34
Q

d. Inhaled beclomethasone decreases inflammation in the lung

A

d. True

35
Q

e. decrease plasma glucose levels

A

e. False. Increase glucose output from the liver

36
Q

In the clinical use of glucocorticosteroids the following is/are true
a. topically applied glucocorticosteroid cream causes thinning of the skin

A

a. True.

37
Q

b. inhaled glucocorticosteroids increases the risk of oesophageal candidiasis

A

b. True,

38
Q

c. prednisone stimulates osteoblast activity in bone

A

c. False, osteoclast activity

39
Q

d. long term oral glucocorticosteroid use increases skeletal muscle strength

A

d. False, catabolism

40
Q

e. dexamethasone-induced lipocortin inhibits the action of phosphlipase A2

A

e. True.

41
Q

In the clinical use of glucocorticosteroids

a. dexamethasone causes suppression of the hypothalamic-pituitary–adrenal axis

A

a. True

42
Q

b. oral glucocorticosteroids suppress inflammation in rheumatoid arthritis

A

b. True

43
Q

c. hydrocortisone is contraindicated in the management of an acute adrenal crisis

A

c. False, managed with parenteral hydrocortisone

44
Q

d. orally administered prednisolone decreases plasma glucose levels

A

d. False, increases

45
Q

e. topically applied hydrocortisone causes thinning of the skin

A

e. True

46
Q

Glucocorticosteroids

a. stimulate interleukin-2 synthesis

A

a. False. Inhibit by inhibiting phospholipase A2

47
Q

b. oral hydrocortisone use has a catabolic effect on muscle

A

b. True

48
Q

c. fluticasone inhibits the inflammatory response in the lungs

A

c. True

49
Q

d. budesonide is used to treat oral candidiasis

A

d. False, oral candidiasis is an adverse effect

50
Q

e. in the elderly, orally administered prednisolone increases the risk of hypertension

A

e. True

Pharm Final (25 decks)

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