Glucorticosteroids questions

Question 1

Effects of oral glucocorticosteroid use (>1 month)

a. decreased blood glucose levels

Answer 1

a. False. Increased

Question 2

Effects of oral glucocorticosteroid use (>1 month)

b.osteoporosis

Answer 2

b. True.

Question 3

Effects of oral glucocorticosteroid use (>1 month)

c.anabolic effect on muscle

Answer 3

c. False. Catabolic

Question 4

Effects of oral glucocorticosteroid use (>1 month)

d. increased susceptibility to infection

Answer 4

d. True. Suppresses the immune response

Question 5

Effects of oral glucocorticosteroid use (>1 month)

e. oedema in the elderly

Answer 5

e. True. Cause sodium retention. Therefore, cause oedema

Question 6

Glucocorticosteroids

a. excessive use causes the suppression of the hypothalamic-pituitary-adrenal axis

Answer 6

a. True

Question 7

Glucocorticosteroids

b oral glucocorticosteroids are contraindicated in the management of auto-immune disease

Answer 7

b. False. They are used to treat

Question 8

Glucocorticosteroids

c.stimulate lung maturation in premature neonates

Answer 8

c. True

Question 9

Glucocorticosteroids

d. prevents the formation of NSAID-associated gastric ulceration

Answer 9

d. False. Increase the likelihood

Question 10

Glucocorticosteroids

e. topically applied hydrocortisone does not cause thinning of the skin

Answer 10

e. False. All cause skin thinning

Question 11

The effects of glucocorticosteroids include

a. anti-inflammatory

Answer 11

a. True

Question 12

The effects of glucocorticosteroids include

b. stimulates the T-cell response

Answer 12

b. False. inhibit the immune response

Question 13

The effects of glucocorticosteroids include

c. increases the response to vaccines

Answer 13

c. False. inhibits the immune response

Question 14

The effects of glucocorticosteroids included. decreases prostaglandin synthesis

Answer 14

d. True

Question 15

The effects of glucocorticosteroids include

e. stimulates wound healing

Answer 15

e. False

Question 16

In the therapeutic use of glucocorticosteroids

a. oral prednisolone increases blood glucose levels

Answer 16

a. True

Question 17

b. glucocorticosteroid receptors are located in the cell membrane

Answer 17

b. False. BINDS Cytoplasmic glucocorticoid receptor

Question 18

c. repeated cortisone injections increase the risk of osteonecrosis

Answer 18

c. True

Question 19

d. in the elderly, oral glucocoticosteroid use increases fluid retention

Answer 19

d. True. increases sodium retention. Therefore, increases fluid retention

Question 20

e. the use of oral methylprednisolone for more than two weeks increases circulating levels of ACTH

Answer 20

e. False

Question 21

Corticosteroids

a. prednisone inhibits COX-I and COX-II

Answer 21

a. True. Steroids inhbit the genes encoding lipocortin. Therefore, decrease synthesis. Lipocortin stimulates phospholipase A2. PA2 stimulates cyclooxygenase producing COX 1 and 2

Question 22

b. phospholipase A2 is stimulated by lipocortin

Answer 22

b. True.

Question 23

c. beclomethasone is given to asthmatic patients to reduce inflammation

Answer 23

c. True

Question 24

d. cortisone will precipitate allergic reactions

Answer 24

d. False. given for allergic reactions

Question 25

e. corticosteroids modify enzyme activity

Answer 25

e. True.

Question 26

Adverse-effects of corticosteroids | a. corticosteroids have an anabolic effect on muscles and are used as muscle bulkers

Answer 26

a. False. Catabolic

Question 27

b. long-term treatment with prednisone causes dysregulation of the HPA-axis

Answer 27

b. True. Should be weened off

Question 28

c. hydrocortisone stimulates bone growth in children

Answer 28

c. False. Bone catabolism

Question 29

d. glucose levels are elevated with corticosteroid treatment

Answer 29

d. True

Question 30

e. a “moon face” and “buffalo hump” are characteristic of long-term prednisone treatment

Answer 30

e. True.

Question 31

Glucocorticosteroids | a. prednisolone suppresses allergic reactions

Answer 31

a. True

Question 32

b. oral betamethasone increases circulating levels of ACTH

Answer 32

b. False. Low cortisol stimulates ACTH production. Thus, induction of a GCS will decrease ACTH production

Question 33

c. hydrocortisone is used to treat ddison’s disease

Answer 33

c. True

Question 34

d. Inhaled beclomethasone decreases inflammation in the lung

Answer 34

d. True

Question 35

e. decrease plasma glucose levels

Answer 35

e. False. Increase glucose output from the liver

Question 36

In the clinical use of glucocorticosteroids the following is/are true a. topically applied glucocorticosteroid cream causes thinning of the skin

Answer 36

a. True.

Question 37

b. inhaled glucocorticosteroids increases the risk of oesophageal candidiasis

Answer 37

b. True,

Question 38

c. prednisone stimulates osteoblast activity in bone

Answer 38

c. False, osteoclast activity

Question 39

d. long term oral glucocorticosteroid use increases skeletal muscle strength

Answer 39

d. False, catabolism

Question 40

e. dexamethasone-induced lipocortin inhibits the action of phosphlipase A2

Answer 40

e. True.

Question 41

In the clinical use of glucocorticosteroids | a. dexamethasone causes suppression of the hypothalamic-pituitary–adrenal axis

Answer 41

a. True

Question 42

b. oral glucocorticosteroids suppress inflammation in rheumatoid arthritis

Answer 42

b. True

Question 43

c. hydrocortisone is contraindicated in the management of an acute adrenal crisis

Answer 43

c. False, managed with parenteral hydrocortisone

Question 44

d. orally administered prednisolone decreases plasma glucose levels

Answer 44

d. False, increases

Question 45

e. topically applied hydrocortisone causes thinning of the skin

Answer 45

e. True

Question 46

Glucocorticosteroids | a. stimulate interleukin-2 synthesis

Answer 46

a. False. Inhibit by inhibiting phospholipase A2

Question 47

b. oral hydrocortisone use has a catabolic effect on muscle

Answer 47

b. True

Question 48

c. fluticasone inhibits the inflammatory response in the lungs

Answer 48

c. True

Question 49

d. budesonide is used to treat oral candidiasis

Answer 49

d. False, oral candidiasis is an adverse effect

Question 50

e. in the elderly, orally administered prednisolone increases the risk of hypertension

Answer 50

e. True