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Pharm Final > Gout > Flashcards

Gout Flashcards

1
Q

Gout

a. allopurinol is effective in acute attacks

A

A. False. Allopurinol is only administered at least 4 weeks after an attack

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2
Q

Gout

b. probenicid inhibits the reabsorption of uric acid in the kidneys

A

B. True. Prevents the re-absorp5on of UA from the kidney at the PCT

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3
Q

Gout

c. aspirin is used to treat pain and inflammation during an acute attack

A

C. False. Aspirin can exacerbate symptoms

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4
Q

Gout

d. urine is alkalinised with probenecid treatment

A

D. False. Alkalinisation is advised. Uric acid excretion will acidify urine.

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5
Q

Gout

e. corticosteroids are contraindicated during an acute attack

A

E. False, corticosteroids are advised. Aspirin is contraindicated

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6
Q

In the treatment of rheumatoid arthritis and gout

a. methotrexate inhibits the action of tumour necrosis factor

A

a. False, folic acid antagonist that inhibits dihydrofolate reductase

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7
Q

In the treatment of rheumatoid arthritis and gout

b. leflunomide is contraindicated prior to falling pregnant

A

b. True, requires a 2 year wash out period

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8
Q

In the treatment of rheumatoid arthritis and gout

c. infliximab decreases circulating tumour necrosis factor

A

c. True, bind circulating and bound TNFa

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9
Q

In the treatment of rheumatoid arthritis and gout

d. colchicine is used to treat rheumatoid arthritis

A

d. False, colchicine is used to treat acute gouty attacks

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10
Q

In the treatment of rheumatoid arthritis and gout

e. aspirin is used as an analgesic in gout

A

e. False, may exacerbate gouty attacks

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11
Q

Colchicine

a. inhibits phagocytosis

A

a. True, colchicine inhibits phagocytosis

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12
Q

Colchicine

b. inhibits uric acid metabolism

A

b. False, Has no effect on UA metabolism and excretion

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13
Q

Colchicine

c. increases the secretion of uric acid at the proximal convoluted tubule

A

c. False, this probenecid

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14
Q

Colchicine

d. causes diarrhoea is an adverse effect

A

d. True

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15
Q

Colchicine

e. is used as a prophylaxis for gout

A

e. True, used to prevent acute gouty attack

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16
Q

In the treatment of gout:

a. Colchicine causes diarrhoea as an adverse effect

A

a. True, colchicine causes diarrhoea, nausea, vomiting, abdominal pain and can lead to bone marrow toxicity and hair loss

17
Q

In the treatment of gout:

b. Probenecid inhibits phagocytosis

A

b. False, probenecid is a uricosuric

18
Q

In the treatment of gout:

c. Colchicine is a xanthine oxidase inhibitor

A

c. False, allopurinol is a xanthine oxidase inhibitor

19
Q

In the treatment of gout:

d. Low dose aspirin is used in the management of acute gouty attack

A

d. False, aspirin is CI

20
Q

In the treatment of gout:

e. Colchicine is preferred to allopurinol in acute gouty attacks’

A

e. True, allopurinol is only administere 4 weeks later

21
Q

Management of gout

a. probenecid is a xanthine oxidase inhibitor

A

a. False, probenecid is a uricosuric

22
Q

Management of gout

b. at low daily doses (< 300 mg), aspirin has uricosuric effects

A

b. False, aspirin is CI in gout

23
Q

Management of gout

c. probenecid increases plasma concentrations of penicillin

A

c. True, decreases the secretion of weak acids like penicillin

24
Q

Management of gout

d. allopurinol inhibits the conversion of hypoxanthine to uric acid

A

d. True, xanthine oxidase inhibitor

25
Q

Management of gout

e. diclofenac reduces inflammation in the gouty joint

A

e. True, cox 2 selective nsaids are used in gout management

26
Q

In the treatment of gout

a. Colchicine causes diarrhoea

A

a. True

27
Q

In the treatment of gout

b. Probenecid inhibits phagocytosis

A

b. False, uricosuric

28
Q

In the treatment of gout

c. Colchicine is a xanthine oxidase inhibitor

A

c. False, inhibits phagocytosis

29
Q

In the treatment of gout

d. Low dose aspirin is used in the management of an acute attack

A

d. False, CI

30
Q

In the treatment of gout

e. Colchicine is preferred to allopurinol in an acute attack of gouty arthritis

A

e. True

31
Q

41-year old male patient with a medical history of acute gouty arthritis was seen by his GP. The patient has noticed skin changes on his ear auricle and fingers. Blood results revealed high serum uric acid levels. The GP confirms that the skin changes are tophi. The doctor prescribes a drug that is a purine-selective xanthine oxidase inhibitor. What is the drug of choice listed below.

A febuxostat - Non-Purine Selective XO Inhibitor
B colchicine - Prevent - precipitation- acute attack
C allopurinol - Purine-selective XO Inhibitor
D etericoxib - COX-2 selective inhibitors

A

Allopurinol

32
Q

A 39-year old man with a history of hypertension and aspirin sensitive asthma experiences excruciating pain in his right ankle only. Microscopic examination of aspirated joint fluid revealed uric acid crystals and he was diagnosed with acute gout. He was prescribed a drug to manage his symptoms. He was told to take two tablets (1mg) immediately and then one tablet (0.5mg) every two hours.
Amer taking a few doses of the prescribed drug he develops severe abdominal pain, nausea and diarrhoea. What is the name the name of the drug that he was prescribed which caused these adverse effects?

A

Colchicine

33
Q

A 35-year old male patient with a medical history of acute gouty arthritis was seen by his GP as a follow up patient. The patient has noticed skin changes on his ear auricle and

fingers. Blood results revealed high serum uric acid levels. The GP has confirmed these skin changes are tophi. His doctor would like to prescribe him a drug that inhibits purine
metabolism. What is the drug of choice for this patient?

A

Allopurinol

Pharm Final (25 decks)

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