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Pharm Final > Bone Homeostasis > Flashcards

Bone Homeostasis Flashcards

1
Q

Bone Homeostasis

a. calcitonin decreases serum calcium

A

a. True

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2
Q

b. alendronate causes oesophagitis

A

b. True

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3
Q

c. parathyroid hormone increases calcium excretion in urine

A

c. False, PTH decreases calcium excretion

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4
Q

d. vitamin D increases calcium absorption in the GIT

A

d. True

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5
Q

e. pamidronate is 90% absorbed from the GIT

A

e. False, Pamidronate is given IV no GI effect

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6
Q

Bone Homeostasis

a. osteoclast resorption is inhibited by calcitonin

A

a. False. Osteoclast activity promoted by PTH and vitamin D. Inhibited by bisphosphonates and estrogens

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7
Q

b. vitamin D inhibits osteoclasts and osteoblasts

A

b. False. Vitamin D stimulates osteoclast activity. Osteoblasts are inhibited by steroids and ethanol

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8
Q

c. hypocalcaemia is treated with calcitonin

A

c. False. Calcitonin will causes hypocalcaemia. Treatment: Ca2+ salts, PTH, Vitamin D

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9
Q

d. alendronate is commonly used in osteoporosis patients

A

d. True. Alendronate and pamidronate are used to treat osteoporosis, glucocorticoidassociated osteoporosis and Paget’s disease

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10
Q

Bone Homeostasis

a. calcitonin decreases serum calcium

A

a. True

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11
Q

b. alendronate causes oesophagitis

A

b. True

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12
Q

c. parathyroid hormone increases calcium excretion in urine

A

c. False

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13
Q

d. vitamin D increases calcium absorption in the GIT

A

d. True

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14
Q

e. pamidronate is 90% absorbed from the GIT

A

e. False. IV

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15
Q

Bone Homeostasis

a. osteoclast resorption is inhibited by calcitonin

A

a. False. Inhibited by bisphosphonates and estrogens

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16
Q

b. vitamin D inhibits osteoclasts and osteoblasts

A

b. False,

17
Q

c. hypocalcaemia is treated with calcitonin

A

c. False

18
Q

d. alendronate is commonly used in osteoporosis patients

A

d. True

19
Q

e. calcium carbonate causes allergic reactions more frequently than calcitonin

A

e. True. Calcium carbonate can causes hypersensitivity reactions, whereas calcitonin is a naturally occurring substance

20
Q

Bone Homeostasis

a. teriparatide is a parathyroid hormone analogue

A

a. True.

21
Q

b. raloxifene stimulates bone resorption

A

b. False, raloxifene inhibits bone resorption

22
Q

c. phytic acid decreases the absorption of calcium

A

c. True. Phytic acid (bran) and oxalic acid (spinach) decreases calcium absorption

23
Q

d. alendronate is used in the treatment of osteoporosis

A

d. True

24
Q

e. alendronate is used to treat oesophageal ulceration

A

e. False. Causes

25
Q

Bone Homeostasis

a. alendronate is administered intravenously

A

a. False. Alendronate is administered orally and pamidronate is administered IV

26
Q

b. raloxifene is a selective estrogen receptor modulator

A

b. True. Raloxifene is a SERM

27
Q

c. bisphosphonates induce osteoclastic bone reabsorption

A

c. False. Bisphosphonates interfere with osteoclastic function and induce osteoclastic apoptosis

28
Q

d. calcitonin increases the renal reabsorption of calcium

A

d. False

29
Q

e. strontium ranelate is used in the treatment of postmenopausal osteoporosis

A

e. True

30
Q

Bone homeostasis

a. Alendronate causes oesophagitis as an adverse effect

A

a. True, administered orally so affects the GIT

31
Q

Bone homeostasis

b. Teriparatide lowers plasma calcium levels via osteoclast inhibition

A

b. False, increases plasma calcium levels through activation of osteoclastic acitvity

32
Q

Bone homeostasis

c. Vitamin D increases bone resorption

A

c. True, osteoclastic activity is stimulated by PTH and vitamin D

33
Q

Bone homeostasis

d. Teriparatide is a parathyroid hormone analogue

A

d. True

34
Q

Bone homeostasis

e. Raloxifene stimulates bone resorption

A

e. False, SERMs inhibit bone resorption

35
Q

Bone homeostasis

f. Phytic acid decreases the absorption of calcium

A

f. True, phytic acid and oxalic acid decrease calcium absorption

36
Q

Bone homeostasis

g. Alendronate is used in the treatment of osteoporosis

A

g. True

Pharm Final (25 decks)

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