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Pharm Final > Asthma and COPD Questions > Flashcards

Asthma and COPD Questions Flashcards

1
Q

MOA for asthma drugs for Asthma and COPD

Tiotropium bromide: muscarinic receptor antagonist

A

a. True.

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2
Q

MOA for asthma drugs for Asthma and COPD

Montelukast: beta 2 adrenoceptor agonist

A

b. False. Leukotriene receptor antagonist

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3
Q

MOA for asthma drugs for Asthma and COPD

Formoterol: beta 2 antagonist

A

c. False. Agonist

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4
Q

MOA for asthma drugs for Asthma and COPD

Theophylline: inhibition of phosphodiesterase

A

d. True

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5
Q

MOA for asthma drugs for Asthma and COPD

Budesonide: inhibit gene transcription

A

e. True. CS

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6
Q

Asthma drugs:

a. Theophylline increases risk of bradycardia in the elderly

A

a. False. Tachycardia

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7
Q

b. A short course of oral prednisone (7-14 days) is used to treat acute exacerbations of asthma

A

b. True

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8
Q

c. Inhaled beclomethasone increases the risk of oropharyngeal candidiasis

A

c. True

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9
Q

d. Oral salbutamol causes tremor

A

d. True

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10
Q

e. Smoking increases plasma concentrations of theophylline

A

e. False. Decreases  increased P450 activity

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11
Q

Asthma and COPD drugs adverse effects:

a. Tiotropium bromide: tremor

A

a. False: Muscarinic antagonist dry mouth, bitter taste, paradoxical bronchoconstriction, urinary retention and constipation (less likely)

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12
Q

Asthma and COPD drugs adverse effects:

b. Montelukast churg-strauss vasculitis

A

b. True (but rare)

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13
Q

Asthma and COPD drugs adverse effects:

c. Oral salbutamol: sedation

A

c. False.

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14
Q

Asthma and COPD drugs adverse effects:

d. Theophylline: seizures

A

d. True

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15
Q

Asthma and COPD drugs adverse effects:

e. Fluticasone: sore throat

A

e. True. ICS

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16
Q

Drugs used in the treatment of Asthma and COPD

a. Formoterol has a faster onset of action than salbutamol

A

a. False. Formoterol is LABA and salbutamol is a SABA

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17
Q

b. Montelukast is used in the management of exercise induced asthma

A

b. True

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18
Q

c. Theophylline clearance is reduced in the elderly

A

c. True

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19
Q

d. Tiotropium bromide causes dry mouth

A

d. True. Muscarinic antagonist

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20
Q

e. IV hydrocortisone is used in the treatment of acute severe ashtma

A

e. True

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21
Q

Asthma/ COPD

a. Inhaled ipratropium bromide has a longer duration of action than tiotropium bromide

A

a. False, tiotropium is long acting

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22
Q

b. Montelukast is used in the treatment of exercise induced asthma

A

b. True

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23
Q

c. Inhaled salbutamol has a slower onset of action than inhaled salmeterol

24
Q

d. Salmeterol is preferred to salbutamol in an acute attack of asthma

25
Q

e. Inhaled beclomethasone causes oropharyngeal candidiasis

26
Q

Drug used in the management of asthma and COPD

a. Fluticasone is b2 receptor agonist

A

a. False. CS

27
Q

b. Clearance of theophylline is reduced in patients over the age of 55

28
Q

c. Inhaled ipratropium bromide causes dry mouth as a side effect

29
Q

d. Montelukast causes nightmares as an adverse effect

30
Q

e. Salbutamol causes bradycardia as an adverse effect

A

e. False. Tachycardia

31
Q

Treatment of asthma and COPD

a. Inhaled salbutamol is indicated for the immediate treatment of acute attacks

32
Q

Treatment of asthma and COPD

b. Inhaled fluticasone is more effective in the treatment of chronic asthma than oral montelukast

A

b. True ? used together stage 3 onwards

33
Q

Treatment of asthma and COPD

c. Inhaled ipratropium bromide is preferred to oral theophylline in the elderly

A

c. True, inhaled ipratropium bromide is the reliever of choice for geriatric patients

34
Q

Asthma drug MOA

a. Fluticasone: regulates the transcription of genes

A

a. True, GCS alter gene transcription

35
Q

Asthma drug MOA
b. Theophylline: antagonists at muscarinic receptors
s

A

b. False, xanthine drugs inhibit phosphodiesterase and antagonise adenosine receptors

36
Q

Asthma drug MOA

c. Montelukast: antagonist at leukotriene receptors

37
Q

Asthma drug MOA

d. Ipratropium bromide: inhibits phosphodiesterase

A

d. False, ipratropium bromide is a muscarinic antagonist

38
Q

Asthma drug MOA

e. Formoterol: agonist at b2 adrenoceptors

A

e. True, salmeterol, formoterol & vilanterol are long acting B2 agonist

39
Q

Asthma drug MOA

f. Aminophylline: antagonist at muscarinic receptors

A

f. False, xanthine drugs inhibit phosphodiesterase and antagonise adenosine receptors

40
Q

Asthma drug MOA

g. Montelukast: lipoxygenase inhibitor

A

g. False, leukotriene receptor antagonist

41
Q

Asthma drug MOA

h. Budesonide: regulates transcription of gene

A

h. True, GCS alter gene transcription

42
Q

Asthma drugs: adverse effects

a. Theophylline: drowsiness

A

a. False, insomnia

43
Q

Asthma drugs: adverse effects

b. Inhaled beclomethasone: bitter taste

44
Q

Asthma drugs: adverse effects

c. Salbutamol: bradycardia

A

c. False, tachycardia

45
Q

Asthma drugs: adverse effects

d. Inhaled ipratropium bromide: dry mouth

A

d. True, muscarinic antagonists will cause dry mouth

46
Q

Asthma drug – Adverse effects

a. theophylline – seizures

47
Q

Asthma drug – Adverse effects

b. inhaled beclomethasone – oropharyngeal candidiasis

A

b. True, need to rinse mouth

48
Q

Asthma drug – Adverse effects

c. salmeterol – bradycardia

A

c. False, tachycardia

49
Q

Asthma drug – Adverse effects

d. ipratropium bromide – salivation

A

d. False, muscarinic antagonist will cause dry mouth

50
Q

Asthma drug – Adverse effects

e. montelukast – Churg Strauss syndrome

A

e. True, but rare

51
Q

Treatment of asthma and COPD

a. the clearance of theophylline is reduced in the elderly

A

a. True, in geriatrics and young infants

52
Q

Treatment of asthma and COPD

b. inhaled beclomethasone reduces inflammation in the airways

53
Q

Treatment of asthma and COPD

c. inhaled ipratropium bromide has longer duration of action than inhaled tiotropium bromide

A

c. False, tiotropium bromide is long acting

54
Q

Treatment of asthma and COPD

d. fluticasone and salmeterol combination therapy is used for the treatment of chronic asthma

55
Q

Treatment of asthma and COPD

e. nebulized salmeterol is used in the treatment of an acute exacerbation of asthma

A

e. False, salmeterol is a laba and not used for acute attacks

Pharm Final (25 decks)

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