Asthma and COPD Questions Flashcards by Josh Datnow

Q

MOA for asthma drugs for Asthma and COPD

Tiotropium bromide: muscarinic receptor antagonist

A

a. True.

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Q

MOA for asthma drugs for Asthma and COPD

Montelukast: beta 2 adrenoceptor agonist

A

b. False. Leukotriene receptor antagonist

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Q

MOA for asthma drugs for Asthma and COPD

Formoterol: beta 2 antagonist

A

c. False. Agonist

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Q

MOA for asthma drugs for Asthma and COPD

Theophylline: inhibition of phosphodiesterase

A

d. True

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Q

MOA for asthma drugs for Asthma and COPD

Budesonide: inhibit gene transcription

A

e. True. CS

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Q

Asthma drugs:

a. Theophylline increases risk of bradycardia in the elderly

A

a. False. Tachycardia

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Q

b. A short course of oral prednisone (7-14 days) is used to treat acute exacerbations of asthma

A

b. True

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Q

c. Inhaled beclomethasone increases the risk of oropharyngeal candidiasis

A

c. True

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Q

d. Oral salbutamol causes tremor

A

d. True

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Q

e. Smoking increases plasma concentrations of theophylline

A

e. False. Decreases  increased P450 activity

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Q

Asthma and COPD drugs adverse effects:

a. Tiotropium bromide: tremor

A

a. False: Muscarinic antagonist dry mouth, bitter taste, paradoxical bronchoconstriction, urinary retention and constipation (less likely)

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Q

Asthma and COPD drugs adverse effects:

b. Montelukast churg-strauss vasculitis

A

b. True (but rare)

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Q

Asthma and COPD drugs adverse effects:

c. Oral salbutamol: sedation

A

c. False.

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Q

Asthma and COPD drugs adverse effects:

d. Theophylline: seizures

A

d. True

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Q

Asthma and COPD drugs adverse effects:

e. Fluticasone: sore throat

A

e. True. ICS

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Q

Drugs used in the treatment of Asthma and COPD

a. Formoterol has a faster onset of action than salbutamol

A

a. False. Formoterol is LABA and salbutamol is a SABA

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Q

b. Montelukast is used in the management of exercise induced asthma

A

b. True

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Q

c. Theophylline clearance is reduced in the elderly

A

c. True

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Q

d. Tiotropium bromide causes dry mouth

A

d. True. Muscarinic antagonist

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Q

e. IV hydrocortisone is used in the treatment of acute severe ashtma

A

e. True

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Q

Asthma/ COPD

a. Inhaled ipratropium bromide has a longer duration of action than tiotropium bromide

A

a. False, tiotropium is long acting

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Q

b. Montelukast is used in the treatment of exercise induced asthma

A

b. True

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Q

c. Inhaled salbutamol has a slower onset of action than inhaled salmeterol

A

c. False

Q

d. Salmeterol is preferred to salbutamol in an acute attack of asthma

A

d. False

e. Inhaled beclomethasone causes oropharyngeal candidiasis

e. True

Drug used in the management of asthma and COPD | a. Fluticasone is b2 receptor agonist

a. False. CS

b. Clearance of theophylline is reduced in patients over the age of 55

b. True

c. Inhaled ipratropium bromide causes dry mouth as a side effect

c. True

d. Montelukast causes nightmares as an adverse effect

d. True

e. Salbutamol causes bradycardia as an adverse effect

e. False. Tachycardia

Treatment of asthma and COPD | a. Inhaled salbutamol is indicated for the immediate treatment of acute attacks

a. True

Treatment of asthma and COPD | b. Inhaled fluticasone is more effective in the treatment of chronic asthma than oral montelukast

b. True ? used together stage 3 onwards

Treatment of asthma and COPD | c. Inhaled ipratropium bromide is preferred to oral theophylline in the elderly

c. True, inhaled ipratropium bromide is the reliever of choice for geriatric patients

Asthma drug MOA | a. Fluticasone: regulates the transcription of genes

a. True, GCS alter gene transcription

Asthma drug MOA b. Theophylline: antagonists at muscarinic receptors s

b. False, xanthine drugs inhibit phosphodiesterase and antagonise adenosine receptors

Asthma drug MOA | c. Montelukast: antagonist at leukotriene receptors

c. True

Asthma drug MOA | d. Ipratropium bromide: inhibits phosphodiesterase

d. False, ipratropium bromide is a muscarinic antagonist

Asthma drug MOA | e. Formoterol: agonist at b2 adrenoceptors

e. True, salmeterol, formoterol & vilanterol are long acting B2 agonist

Asthma drug MOA | f. Aminophylline: antagonist at muscarinic receptors

f. False, xanthine drugs inhibit phosphodiesterase and antagonise adenosine receptors

Asthma drug MOA | g. Montelukast: lipoxygenase inhibitor

g. False, leukotriene receptor antagonist

Asthma drug MOA | h. Budesonide: regulates transcription of gene

h. True, GCS alter gene transcription

Asthma drugs: adverse effects | a. Theophylline: drowsiness

a. False, insomnia

Asthma drugs: adverse effects | b. Inhaled beclomethasone: bitter taste

b. True

Asthma drugs: adverse effects | c. Salbutamol: bradycardia

c. False, tachycardia

Asthma drugs: adverse effects | d. Inhaled ipratropium bromide: dry mouth

d. True, muscarinic antagonists will cause dry mouth

Asthma drug – Adverse effects | a. theophylline – seizures

a. True

Asthma drug – Adverse effects | b. inhaled beclomethasone – oropharyngeal candidiasis

b. True, need to rinse mouth

Asthma drug – Adverse effects | c. salmeterol – bradycardia

c. False, tachycardia

Asthma drug – Adverse effects | d. ipratropium bromide – salivation

d. False, muscarinic antagonist will cause dry mouth

Asthma drug – Adverse effects | e. montelukast – Churg Strauss syndrome

e. True, but rare

Treatment of asthma and COPD | a. the clearance of theophylline is reduced in the elderly

a. True, in geriatrics and young infants

Treatment of asthma and COPD | b. inhaled beclomethasone reduces inflammation in the airways

b. True

Treatment of asthma and COPD | c. inhaled ipratropium bromide has longer duration of action than inhaled tiotropium bromide

c. False, tiotropium bromide is long acting

Treatment of asthma and COPD | d. fluticasone and salmeterol combination therapy is used for the treatment of chronic asthma

d. True

Treatment of asthma and COPD | e. nebulized salmeterol is used in the treatment of an acute exacerbation of asthma

e. False, salmeterol is a laba and not used for acute attacks