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Pharm Final > NMBDs questions > Flashcards

NMBDs questions Flashcards

1
Q

Muscle Relaxants:

a. Baclofen is a GABA mimetic agent

A

a. True. Baclofen is a GABA agonist

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2
Q

b. Vecuronium is a nicotinic receptor antagonist

A

b. True, Vecuronium is a non-depolarizing NMBD. Non-depolarizing NMBDs competitively antagonize ACh at the postsynaptic nicotinic receptor

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3
Q

c. Rifampicin prolongs the muscle relaxant effects of vecuronium

A

c. False. Rifampicin induces cytochrome p450 enzymes, which metabolize vecuronium in the liver. Therefore, reducing the effect

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4
Q

d. Atropine inhibits acetylcholinesterase

A

d. False. Neostigmine inhibits ach-e. Atropine blocks muscarinic receptors

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5
Q

e. Vecuronium induces more histamine release than pancuronium

A

e. False. Most non-depolarizing NMBDs release histamine except rocuronium

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6
Q

Succinylcholine:

a. Is a non-depolarizing neuromuscular blocker

A

a. False. Succinylcholine is the only depolarizing NMBD in use

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7
Q

Succinylcholine:

b. Has a faster onset of action than cis-atracurium

A

b. True. Fast acting

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8
Q

Succinylcholine:

c. Competes with mivacurium for plasma cholinesterase

A

c. True, Both are metabolized by plasma cholinestares

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9
Q

Succinylcholine:

d. Is used to treat malignant hyperthermia

A

d. F. Causes malignant hyperthermia

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10
Q

Succinylcholine:

e. Causes hypertension

A

e. False. Causes hypotension.

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11
Q

Neuromuscular Blocking agents

a. vecuronium antagonizes the effects of acetylcholine at the post synaptic nicotinic receptor

A

a. True. Non-depolarizing NMBDs competitively antagonize ACh at the postsynaptic nicotinic receptor

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12
Q

b. cis-atracurium is metabolized in the liver

A

b. False. Spontaneous (Hoffman) degradation. Drug of choice in liver failure

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13
Q

c. pancuronium has a longer duration of action than succinylcholine

A

c. True. Pancuronium is long lasting

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14
Q

d. vecuronium crosses the blood brain barrier

A

d. False ND-NMBD do not cross the BBB or placenta

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15
Q

e. succinylcholine reverses muscle rigidity in patients with malignant hyperthermia

A

e. False. Malignant hyperthermia is a consequence of succinylcholine

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16
Q

Muscle relaxants

a. dantrolene activates the calcium channel in the sarcoplasmic reticulum

A

a. False. Dantrolene inhibits the release of calcium

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17
Q

b. baclofen is an agonist at GABA-B receptors

A

b. True

18
Q

Muscle relaxants

a. dantrolene activates the calcium channel in the sarcoplasmic reticulum

A

a. False. Dantrolene inhibits the release of calcium

.

19
Q

b. baclofen is an agonist at GABA-B receptors

A

b. True

20
Q

c. orphenadrine is contraindicated in glaucoma

A

c. True

21
Q

d. diazepam enhances the effects of GABA in the spinal cord

A

d. False, diazepam is effective for spasticity of a cerebral origin. Baclofen is used for spinal

22
Q

e. methocarbamol is indicated in the treatment of myasthenia gravis

A

e. False

23
Q

Non-Depolarising neuromuscular blockers

a. include mivacurium

A

a. True. Mivacurium, atracurium, vecuronium, rocuronium, d-tubocurarine and pancuronium

24
Q

Non-Depolarising neuromuscular blockers

b. are administered intravenously

A

b. True.

25
Q

Non-Depolarising neuromuscular blockers

c. cause sedation

A

c. False. Cause hypotension and bronchospasm, Pancuronium causes tachycardia and elevated BP

26
Q

Non-Depolarising neuromuscular blockers

d. are metabolised by acetylcholinesterases

A

d. False, deplorizing NMBDs

27
Q

Non-Depolarising neuromuscular blockers

e. have a faster onset of action than depolarising neuromuscular blockers

A

e. False.

28
Q

Depolarising neuromuscular blockers

a. include mivacurium

A

a. False, Succinylcholine

29
Q

Depolarising neuromuscular blockers

b. are administered orally

A

b. False.

30
Q

Depolarising neuromuscular blockers

c. have a faster onset than non-depolarising neuromuscular blockers

A

c. True

31
Q

Depolarising neuromuscular blockers

d. are metabolised by acetylcholinesterases

A

d. True Metabolism: quickly hydrolyzed plasma pseudocholinesterases

32
Q

Neuromuscular blocking agents

a. succinylcholine has a slower onset of action than vecuronium

A

a. False, depolarizing much quicker

33
Q

b. neostigmine reverses the muscle relaxant effects of cis-atracurium

A

b. True.

34
Q

c. vecuronium induces the release of more histamine than pancuronium

A

c. False, all have histamine except rocuronium

35
Q

d. succinylcholine causes malignant hyperthermia as an adverse effect

A

d. True

36
Q

e. morphine potentiates the respiratory depressant effects of vecuronium

A

e. False. Vecuronium doesn’t cause respiratory depression

37
Q

Vecuronium

a. is metabolised by plasma cholinesterase

A

a. False. Liver

38
Q

Vecuronium

b. has a longer duration of action than succinylcholine

A

b. True

39
Q

Vecuronium

c. is less cardiotoxic than pancuronium

A

c. True, pancuronium causes Increased pulse rate Increased cardiac output Increased blood pressure Arrhythmias

40
Q

Vecuronium

e. crosses the blood-brain barrier

A

e. False. Non-depolarizing NMBD do not cross the BBB

Pharm Final (25 decks)

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