NMBDs questions

Question 1

Muscle Relaxants:

a. Baclofen is a GABA mimetic agent

Answer 1

a. True. Baclofen is a GABA agonist

Question 2

b. Vecuronium is a nicotinic receptor antagonist

Answer 2

b. True, Vecuronium is a non-depolarizing NMBD. Non-depolarizing NMBDs competitively antagonize ACh at the postsynaptic nicotinic receptor

Question 3

c. Rifampicin prolongs the muscle relaxant effects of vecuronium

Answer 3

c. False. Rifampicin induces cytochrome p450 enzymes, which metabolize vecuronium in the liver. Therefore, reducing the effect

Question 4

d. Atropine inhibits acetylcholinesterase

Answer 4

d. False. Neostigmine inhibits ach-e. Atropine blocks muscarinic receptors

Question 5

e. Vecuronium induces more histamine release than pancuronium

Answer 5

e. False. Most non-depolarizing NMBDs release histamine except rocuronium

Question 6

Succinylcholine:

a. Is a non-depolarizing neuromuscular blocker

Answer 6

a. False. Succinylcholine is the only depolarizing NMBD in use

Question 7

Succinylcholine:

b. Has a faster onset of action than cis-atracurium

Answer 7

b. True. Fast acting

Question 8

Succinylcholine:

c. Competes with mivacurium for plasma cholinesterase

Answer 8

c. True, Both are metabolized by plasma cholinestares

Question 9

Succinylcholine:

d. Is used to treat malignant hyperthermia

Answer 9

d. F. Causes malignant hyperthermia

Question 10

Succinylcholine:

e. Causes hypertension

Answer 10

e. False. Causes hypotension.

Question 11

Neuromuscular Blocking agents

a. vecuronium antagonizes the effects of acetylcholine at the post synaptic nicotinic receptor

Answer 11

a. True. Non-depolarizing NMBDs competitively antagonize ACh at the postsynaptic nicotinic receptor

Question 12

b. cis-atracurium is metabolized in the liver

Answer 12

b. False. Spontaneous (Hoffman) degradation. Drug of choice in liver failure

Question 13

c. pancuronium has a longer duration of action than succinylcholine

Answer 13

c. True. Pancuronium is long lasting

Question 14

d. vecuronium crosses the blood brain barrier

Answer 14

d. False ND-NMBD do not cross the BBB or placenta

Question 15

e. succinylcholine reverses muscle rigidity in patients with malignant hyperthermia

Answer 15

e. False. Malignant hyperthermia is a consequence of succinylcholine

Question 16

Muscle relaxants

a. dantrolene activates the calcium channel in the sarcoplasmic reticulum

Answer 16

a. False. Dantrolene inhibits the release of calcium

Question 17

b. baclofen is an agonist at GABA-B receptors

Answer 17

b. True

Question 18

Muscle relaxants

a. dantrolene activates the calcium channel in the sarcoplasmic reticulum

Answer 18

a. False. Dantrolene inhibits the release of calcium

.

Question 19

b. baclofen is an agonist at GABA-B receptors

Answer 19

b. True

Question 20

c. orphenadrine is contraindicated in glaucoma

Answer 20

c. True

Question 21

d. diazepam enhances the effects of GABA in the spinal cord

Answer 21

d. False, diazepam is effective for spasticity of a cerebral origin. Baclofen is used for spinal

Question 22

e. methocarbamol is indicated in the treatment of myasthenia gravis

Answer 22

e. False

Question 23

Non-Depolarising neuromuscular blockers

a. include mivacurium

Answer 23

a. True. Mivacurium, atracurium, vecuronium, rocuronium, d-tubocurarine and pancuronium

Question 24

Non-Depolarising neuromuscular blockers

b. are administered intravenously

Answer 24

b. True.

Question 25

Non-Depolarising neuromuscular blockers | c. cause sedation

Answer 25

c. False. Cause hypotension and bronchospasm, Pancuronium causes tachycardia and elevated BP

Question 26

Non-Depolarising neuromuscular blockers | d. are metabolised by acetylcholinesterases

Answer 26

d. False, deplorizing NMBDs

Question 27

Non-Depolarising neuromuscular blockers | e. have a faster onset of action than depolarising neuromuscular blockers

Answer 27

e. False.

Question 28

Depolarising neuromuscular blockers | a. include mivacurium

Answer 28

a. False, Succinylcholine

Question 29

Depolarising neuromuscular blockers | b. are administered orally

Answer 29

b. False.

Question 30

Depolarising neuromuscular blockers c. have a faster onset than non-depolarising neuromuscular blockers

Answer 30

c. True

Question 31

Depolarising neuromuscular blockers | d. are metabolised by acetylcholinesterases

Answer 31

d. True Metabolism: quickly hydrolyzed plasma pseudocholinesterases

Question 32

Neuromuscular blocking agents | a. succinylcholine has a slower onset of action than vecuronium

Answer 32

a. False, depolarizing much quicker

Question 33

b. neostigmine reverses the muscle relaxant effects of cis-atracurium

Answer 33

b. True.

Question 34

c. vecuronium induces the release of more histamine than pancuronium

Answer 34

c. False, all have histamine except rocuronium

Question 35

d. succinylcholine causes malignant hyperthermia as an adverse effect

Answer 35

d. True

Question 36

e. morphine potentiates the respiratory depressant effects of vecuronium

Answer 36

e. False. Vecuronium doesn't cause respiratory depression

Question 37

Vecuronium a. is metabolised by plasma cholinesterase

Answer 37

a. False. Liver

Question 38

Vecuronium | b. has a longer duration of action than succinylcholine

Answer 38

b. True

Question 39

Vecuronium | c. is less cardiotoxic than pancuronium

Answer 39

c. True, pancuronium causes Increased pulse rate Increased cardiac output Increased blood pressure Arrhythmias

Question 40

Vecuronium e. crosses the blood-brain barrier

Answer 40

e. False. Non-depolarizing NMBD do not cross the BBB